ArticleGenes and immunity2002
A genome screen for linkage in Australian sibling-pairs with multiple sclerosis.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mapping candidate non-MHC susceptibility regions to multiple sclerosis.Genes and immunity · 2006Pooled it
- Astrocytic TIMP-1 regulates production of Anastellin, an inhibitor of oligodendrocyte differentiation and FTY720 responses.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A review of genome-wide association studies for multiple sclerosis: classical and hypothesis-driven approaches.Human genetics · 2015Review
- The BMP signaling pathway at the Drosophila neuromuscular junction and its links to neurodegenerative diseases.Current opinion in neurobiology · 2011Review
- Follow-up examination of linkage and association to chromosome 1q43 in multiple sclerosis.Genes and immunity · 2009Article
- The genetic aspects of multiple sclerosis.Annals of Indian Academy of Neurology · 2009Article
- The complex genetics of multiple sclerosis: pitfalls and prospects.Brain : a journal of neurology · 2008Review
- The role of hereditary spastic paraplegia related genes in multiple sclerosis. A study of disease susceptibility and clinical outcome.Journal of neurology · 2007Article
- A genome-wide scan in forty large pedigrees with multiple sclerosis.Journal of human genetics · 2007Article
- Follow-up investigation of 12 proposed linkage regions in multiple sclerosis.Genes and immunity · 2006Article
- Article
- Examination of seven candidate regions for multiple sclerosis: strong evidence of linkage to chromosome 1q44.Genes and immunity · 2006Article
- A high-density screen for linkage in multiple sclerosis.American journal of human genetics · 2005Article
- Eae19, a new locus on rat chromosome 15 regulating experimental autoimmune encephalomyelitis.Genetics · 2005Article
- A second-generation genomic screen for multiple sclerosis.American journal of human genetics · 2004Article
- Whole-genome scan, in a complex disease, using 11,245 single-nucleotide polymorphisms: comparison with microsatellites.American journal of human genetics · 2004Article
- Looking back and looking forward.Genes and immunity · 2003Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of genetic factors in determining susceptibility to multiple sclerosis is well established but, despite the global distribution of the disease, systematic efforts to locate susceptibility genes have concentrated exclusively on populations from the Northern Hemisphere. We performed a genome wide screen of linkage in the Australian population using a panel of 397 microsatellite markers in 54 affected sibling-pairs. Multipoint linkage analysis revealed four regions of suggestive linkage (on chromosomes 2p13, 4q26-28, 6q26 and Xp11) and 18 additional regions of potential linkage (at 1q43-44, 3q13-24, 4q24, 4q31-34, 5q11-13, 6q27, 7q33-35, 8p23-21, 9q21, 13q31-32, 16p13, 16p11, 16q23-24, 17p13, 18p11, 20p12-11, Xp21-11 and Xq23-28). Our results contribute to the available data adding new provisional regions of linkage as well as increasing support for areas previously implicated in genetic susceptibility to multiple sclerosis.
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