ArticleGenes and immunity2002
Association tests with systemic lupus erythematosus (SLE) of IL10 markers indicate a direct involvement of a CA repeat in the 5' regulatory region.
Article in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Lack of association between interleukin-10, transforming growth factor-beta gene polymorphisms and juvenile-onset systemic lupus erythematosus.Clinical rheumatology · 2015Article
- Role of interleukin-10 and interleukin-10 receptor in systemic lupus erythematosus.Clinical rheumatology · 2013Review
- IL-10 and TNFalpha genotypes in SLE.Journal of biomedicine & biotechnology · 2010Review
- The genetics and epigenetics of autoimmune diseases.Journal of autoimmunity · 2009Review
- A sequence variation in the MOG gene is involved in multiple sclerosis susceptibility in Italy.Genes and immunity · 2008Article
- Current status of lupus genetics.Arthritis research & therapy · 2007Review
- Association of apoptosis-related microsatellite polymorphisms on chromosome 1q in Taiwanese systemic lupus erythematosus patients.Clinical and experimental immunology · 2006Article
- Polymorphisms of complement receptor 1 and interleukin-10 genes and systemic lupus erythematosus: a meta-analysis.Human genetics · 2005Article
- Polymorphism of the mouse gene for the interleukin 10 receptor alpha chain (Il10ra) and its association with the autoimmune phenotype.Immunogenetics · 2005Article
- Natural killer cell activity in families of patients with systemic lupus erythematosus: demonstration of a killing defect in patients.Clinical and experimental immunology · 2005Article
- Association of interleukin-10 promoter polymorphisms with systemic lupus erythematosus.Genes and immunity · 2004Article
- Looking back and looking forward.Genes and immunity · 2003Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many lines of evidence suggest that IL10 is a strong candidate gene for systemic lupus erythematosus (SLE) susceptibility. In our previously reported study an allele (IL10.G-140bp) of the microsatellite IL10.G located at position -1100 was significantly increased in Italian SLE patients in comparison with controls. Starting from this observation, we tested if sequence variations in the vicinity of IL10.G were more strongly associated with SLE. We performed a comprehensive association study including 26 SNPs (of which four were newly identified in the present study by DHPLC analysis) spanning 8.5 Kb of the 5' flanking and the transcribed region of the IL10 gene. The association study was performed by the DNA pool method on an extended panel of Italian patients (205) and controls (631). Haplotypic associations were studied by individual typing of seven selected markers surrounding IL10.G. Gene, genotype and haplotype frequencies were not significantly different in patients and controls. Thus the IL10.G microsatellite remains to date the only IL10 marker associated with SLE in our population. A meta-analysis of all published results indicates a possible direct role of the IL10.G repeat number in SLE susceptibility.
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