ReviewGenes and immunity2002
Genetics of susceptibility to leprosy.
Review in Genes and immunity, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 114 citations in OpenAlex.
- ncRNAs: an unexplored cellular defense mechanism in leprosy.Frontiers in genetics · 2023Review
- Autochthonous North American Leprosy: A Second Case in Canada.Infectious disease reports · 2021Article
- The immunology of other mycobacteria: M. ulcerans, M. leprae.Seminars in immunopathology · 2020Review
- VDR polymorphism, gene expression and vitamin D levels in leprosy patients from North Indian population.PLoS neglected tropical diseases · 2018Article
- Human complement receptor type 1 (CR1) protein levels and genetic variants in chronic Chagas Disease.Scientific reports · 2018Article
- Geographical distribution of complement receptor type 1 variants and their associated disease risk.PloS one · 2017Article
- Factors associated with acquired Anti IFN- γ autoantibody in patients with nontuberculous mycobacterial infection.PloS one · 2017Article
- Evaluation and Monitoring of Mycobacterium leprae Transmission in Household Contacts of Patients with Hansen's Disease in Colombia.PLoS neglected tropical diseases · 2017Article
- Genetic variations in vitamin D receptor were associated with the outcomes of hepatitis C virus infection among Chinese population.Journal of human genetics · 2016Article
- Human leukocyte antigen class I and class II alleles are associated with susceptibility and resistance in borderline leprosy patients from Southeast Brazil.BMC infectious diseases · 2015Article
- Human Genetic Ancestral Composition Correlates with the Origin of Mycobacterium leprae Strains in a Leprosy Endemic Population.PLoS neglected tropical diseases · 2015Article
- Gene Association with Leprosy: A Review of Published Data.Frontiers in immunology · 2015Review
- Article
- Protein tyrosine phosphatase non-receptor type 22 gene polymorphism C1858T is not associated with leprosy in Azerbaijan, Northwest Iran.Indian journal of human genetics · 2013Article
- Vitamin D receptor gene polymorphism in children with urinary tract infection.Pediatric nephrology (Berlin, Germany) · 2012Article
- Leprosy as a genetic disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Review
- Human polymorphisms as clinical predictors in leprosy.Journal of tropical medicine · 2011Article
- Vitamin D signaling, infectious diseases, and regulation of innate immunity.Infection and immunity · 2008Review
- Leprosy as a genetic model for susceptibility to common infectious diseases.Human genetics · 2008Review
- Toll-like receptor 2 (TLR2) polymorphisms are associated with reversal reaction in leprosy.The Journal of infectious diseases · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The ancient disease of leprosy can cause severe disability and disfigurement and is still a major health concern in many parts of the world. Only a subset of those individuals exposed to the pathogen will go on to develop clinical disease and there is a broad clinical spectrum amongst leprosy sufferers. The outcome of infection is in part due to host genes that influence control of the initial infection and the host's immune response to that infection. Identification of the host genes that influence host susceptibility/resistance will enable a greater understanding of disease pathogenesis. In turn, this should facilitate development of more effective therapeutics and vaccines. So far at least a dozen genes have been implicated in leprosy susceptibility and a genome-wide linkage study has lead to the identification of at least one positional candidate. These findings are reviewed here.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.