ArticleProceedings of the National Academy of Sciences of the United States of America2002
Effects of strand and directional asymmetry on base-base coupling and charge transfer in double-helical DNA.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 77 citations in OpenAlex.
- From single step hops to emergent biological phenomena.Journal of inorganic biochemistry · 2026Review
- Rationalizing the environment-dependent photophysical behavior of a DNA luminescent probe by classical and non-adiabatic molecular dynamics simulations.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2023Article
- Probing RNA Structures and Interactions Using Fluorescence Lifetime Analyses.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Relation between DNA ionization potentials, single base substitutions and pathogenic variants.BMC genomics · 2019Article
- Positional Dependence of DNA Hole Transfer Efficiency in Nucleosome Core Particles.Journal of the American Chemical Society · 2019Article
- DNA Damage Emanating From a Neutral Purine Radical Reveals the Sequence Dependent Convergence of the Direct and Indirect Effects of γ-Radiolysis.Journal of the American Chemical Society · 2017Article
- Cobalt(III)hexaammine-dependent photocrosslinks in the hairpin ribozyme.Journal of inorganic biochemistry · 2014Article
- Exciplexes and conical intersections lead to fluorescence quenching in π-stacked dimers of 2-aminopurine with natural purine nucleobases.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2013Article
- Solution, surface, and single molecule platforms for the study of DNA-mediated charge transport.Physical chemistry chemical physics : PCCP · 2012Review
- Integration specificity of LTR-retrotransposons and retroviruses in the Drosophila melanogaster genome.Virus genes · 2011Article
- Metal Complexes for DNA-Mediated Charge Transport.Coordination chemistry reviews · 2011Article
- Single-step charge transport through DNA over long distances.Journal of the American Chemical Society · 2011Article
- DNA-mediated electron transfer in naphthalene-modified oligonucleotides.The Journal of organic chemistry · 2010Article
- Mechanisms for DNA charge transport.Chemical reviews · 2010Review
- Back-electron transfer suppresses the periodic length dependence of DNA-mediated charge transport across adenine tracts.Journal of the American Chemical Society · 2008Article
- UV excitation of single DNA and RNA strands produces high yields of exciplex states between two stacked bases.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- An ultrasensitive photoelectrochemical nucleic acid biosensor.Nucleic acids research · 2005Article
- Unusual 2-aminopurine fluorescence from a complex of DNA and the EcoKI methyltransferase.Nucleic acids research · 2004Article
- Determination of DNA guanine sites forming photo-adducts with Ru(II)-labeled oligonucleotides; DNA polymerase inhibition by the resulting photo-crosslinking.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2004Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Mechanistic models of charge transfer (CT) in macromolecules often focus on CT energetics and distance as the chief parameters governing CT rates and efficiencies. However, in DNA, features unique to the DNA molecule, in particular, the structure and dynamics of the DNA base stack, also have a dramatic impact on CT. Here we probe the influence of subtle structural variations on base-base CT within a DNA duplex by examining photoinduced quenching of 2-aminopurine (Ap) as a result of hole transfer (HT) to guanine (G). Photoexcited Ap is used as a dual reporter of variations in base stacking and CT efficiency. Significantly, the unique features of DNA, including the strandedness and directional asymmetry of the double helix, play a defining role in CT efficiency. For an (AT)n bridge, the orientation of the base pairs is critical; the yield of intrastrand HT is markedly higher through (A)n compared with (T)n bridges, whereas HT via intrastrand pathways is more efficient than through interstrand pathways. Remarkably, for reactions through the same DNA bridge, over the same distance, and with the same driving force, HT from photoexcited Ap to G in the 5' to 3' direction is more efficient and less dependent on distance than HT from 3' to 5'. We attribute these differences in HT efficiency to variations in base-base coupling within the DNA assemblies. Thus base-base coupling is a critical parameter in DNA CT and strongly depends on subtle structural nuances of duplex DNA.
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