ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Alpha 4 integrins and vascular cell adhesion molecule-1 play a role in sympathetic innervation of the heart.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Development and modeling of cardiac autonomic innervation.Nature cardiovascular research · 2025Review
- The exit of axons and glial membrane from the developing Drosophila retina requires integrins.Molecular brain · 2022Article
- Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease.Scientific reports · 2016Article
- Eph/ephrin interactions modulate vascular sympathetic innervation.Autonomic neuroscience : basic & clinical · 2010Article
- The synaptic proteins neurexins and neuroligins are widely expressed in the vascular system and contribute to its functions.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- VEGF-A and Semaphorin3A: modulators of vascular sympathetic innervation.Developmental biology · 2009Article
- Statins decrease dendritic arborization in rat sympathetic neurons by blocking RhoA activation.Journal of neurochemistry · 2009Article
- Advancing age alters the expression of the ryanodine receptor 3 isoform in adult rat superior cervical ganglia.Journal of applied physiology (Bethesda, Md. : 1985) · 2006Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
Sympathetic neurons innervate the heart early in postnatal development, an event that is crucial for proper modulation of blood pressure and cardiac function. However, the axon guidance cues that direct sympathetic neurons to the heart, and the neuronal receptors that recognize those cues, are poorly understood. Here we present evidence that interactions between the alpha4beta1 integrin on sympathetic neurons and vascular cell adhesion molecule-1 (VCAM-1) in the heart plays a role in cardiac innervation. The alpha4 subunit was detected on postnatal rat superior cervical ganglion (SCG) neurons in culture and in cryosections of SCG and heart. VCAM-1 immunoreactivity was detected on cardiac myocytes that associate with invading sympathetic neurons. Purified recombinant soluble VCAM-1 (rsVCAM-1) stimulated SCG neurite outgrowth at levels comparable with laminin 2/4 and fibronectin (Fn), and outgrowth on rs-VCAM-1 and Fn was blocked by antibodies specific for the alpha4 and beta1 integrin subunits. Intrathoracic injection of function-blocking antibodies to alpha4 and VCAM-1, as well as a small molecule inhibitor of alpha4 integrins, significantly reduced sympathetic innervation of the heart. These results indicate that the interaction between alpha4 integrin and VCAM-1 is important for sympathetic innervation of the heart.
Indexed as
Identifiers
12486170PMC6758413W1544802999What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.