ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Modulation of the readily releasable pool of transmitter and of excitation-secretion coupling by activity and by serotonin at Aplysia sensorimotor synapses in culture.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 35 citations in OpenAlex.
- The role of specific isoforms of CaScientific reports · 2023Article
- Excitatory postsynaptic calcium transients atLearning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- BK Channels Mediate Synaptic Plasticity Underlying Habituation in Rats.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Persistent Associative Plasticity at an Identified Synapse Underlying Classical Conditioning Becomes Labile with Short-Term Homosynaptic Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Decline in the Recovery from Synaptic Depression in Heavier Aplysia Results from Decreased Serotonin-Induced Novel PKC Activation.PloS one · 2015Article
- Contribution of PKC to the maintenance of 5-HT-induced short-term facilitation at sensorimotor synapses of Aplysia.Journal of neurophysiology · 2014Article
- Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Rescue of tau-induced synaptic transmission pathology by paclitaxel.Frontiers in cellular neuroscience · 2014Article
- Neuropeptide y gates a stress-induced, long-lasting plasticity in the sympathetic nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Release properties of individual presynaptic boutons expressed during homosynaptic depression and heterosynaptic facilitation of the Aplysia sensorimotor synapse.Frontiers in cellular neuroscience · 2013Article
- Protein kinase C acts as a molecular detector of firing patterns to mediate sensory gating in Aplysia.Nature neuroscience · 2012Article
- State-dependent disruption of short-term facilitation due to overexpression of the apPDE4 supershort form in Aplysia.Molecules and cells · 2011Article
- Presynaptic and postsynaptic mechanisms of synaptic plasticity and metaplasticity during intermediate-term memory formation in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- Auditory stimulation dishabituates olfactory responses via noradrenergic cortical modulation.Neural plasticity · 2009Article
- Burst-induced synaptic depression and its modulation contribute to information transfer at Aplysia sensorimotor synapses: empirical and computational analyses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Calcium-activated proteases are critical for refilling depleted vesicle stores in cultured sensory-motor synapses of Aplysia.Learning & memory (Cold Spring Harbor, N.Y.)Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 2 countries.
Funding
Abstract
Short-term homosynaptic depression and heterosynaptic facilitation of transmitter release from mechanoreceptor sensory neurons of Aplysia are involved in habituation and sensitization, respectively, of defensive withdrawal reflexes. We investigated whether synaptic transmission is regulated in these forms of plasticity by means of changes in the size of the pool of transmitter available for immediate release [the readily releasable pool (RRP)] or in the efficacy of release from an unchanging pool. Using sensorimotor synapses formed in cell culture, we estimated the number of transmitter quanta in the RRP from the asynchronous release of neurotransmitter caused by application of a hypertonic bathing solution. Our experiments indicate that the transmitter released by action potentials and by hypertonic solution comes from the same pool. The RRP was reduced after homosynaptic depression of the EPSP by low-frequency stimulation and increased after facilitation of the EPSP by application of the endogenous facilitatory transmitter serotonin (5-HT) after homosynaptic depression. However, although the fractional changes in the RRP and in the EPSP were similar for both synaptic depression and facilitation when depression was induced by repeated hypertonic stimulation, the changes in the EPSP were significantly greater than the changes in the RRP when depression was induced by repeated electrical stimulation. These observations indicate that homosynaptic depression and restoration of depressed transmission by 5-HT are caused by changes in both the amount of transmitter available for immediate release and in processes involved in the coupling of the action potential to transmitter release.
Indexed as
Identifiers
12486160PMC6758440W2163574537What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.