ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers.
What it found
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The trial behind it
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Who cites it
133 citing papers in PubMed, 323 citations in OpenAlex.
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- PUFA modulation of ASIC3 involves both specific and lipid solvent-like interactions.bioRxiv : the preprint server for biology · 2026Article
- Mechanisms of pain occurrence in osteoarthritis: peripheral triggers, sensitization, and the path to persistence.Frontiers in immunology · 2026Review
- Impact of adolescent ethanol binge on serotonin signaling and pain sensitivity post-withdrawal.Alcohol (Fayetteville, N.Y.) · 2025Article
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- Visceral Pain in Preterm Infants with Necrotizing Enterocolitis: Underlying Mechanisms and Implications for Treatment.Paediatric drugs · 2025Review
- Sensory ASIC3 channel exacerbates psoriatic inflammation via a neurogenic pathway in female mice.Nature communications · 2024Article
- Neurochemical mechanism of muscular pain: Insight from the study on delayed onset muscle soreness.The journal of physiological sciences : JPS · 2024Review
- Mice lacking ASIC2 and βENaC are protected from high-fat-diet-induced metabolic syndrome.Frontiers in endocrinology · 2024Article
- Cancer-nerve interplay in cancer progression and cancer-induced bone pain.Journal of bone and mineral metabolism · 2023Review
- Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors.Nature reviews. Neuroscience · 2023Review
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- Revisiting Migraine: The Evolving Pathophysiology and the Expanding Management Armamentarium.Cureus · 2023Review
- Sensory Phenotype of the Oesophageal Mucosa in Gastro-Oesophageal Reflux Disease.International journal of molecular sciences · 2023Review
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- Spinal Cord Stimulation to Treat Unresponsive Cancer Pain: A Possible Solution in Palliative Oncological Therapy.Life (Basel, Switzerland) · 2022Review
- Pain in chronic prostatitis and the role of ion channels: a brief overview.British journal of pain · 2022Article
- Upregulation of acid sensing ion channels is associated with esophageal hypersensitivity in GERD.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Single Subcutaneous Injection of Lysophosphatidyl-Choline Evokes ASIC3-Dependent Increases of Spinal Dorsal Horn Neuron Activity.Frontiers in molecular neuroscience · 2022Article
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Tissue acidosis is an important feature of inflammation. It is a direct cause of pain and hyperalgesia. Protons activate sensory neurons mainly through acid-sensing ion channels (ASICs) and the subsequent membrane depolarization that leads to action potential generation. We had previously shown that ASIC transcript levels were increased in inflammatory conditions in vivo. We have now found that this increase is caused by the proinflammatory mediators NGF, serotonin, interleukin-1, and bradykinin. A mixture of these mediators increases ASIC-like current amplitude on sensory neurons as well as the number of ASIC-expressing neurons and leads to a higher sensory neuron excitability. An analysis of the promoter region of the ASIC3 encoding gene, an ASIC specifically expressed in sensory neurons and associated with chest pain that accompanies cardiac ischemia, reveals that gene transcription is controlled by NGF and serotonin.
Indexed as
Identifiers
12486159PMC6758460W2151975160What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.