ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Electrical synapses mediate signal transmission in the rod pathway of the mammalian retina.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.
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Who cites it
86 citing papers in PubMed, 161 citations in OpenAlex.
- Defining the electrical synapse.Nature reviews. Neuroscience · 2026Review
- Photomapping electrically coupled networks of the mature thalamus and cortex.Science advances · 2026Article
- Electrical Coupling within Thalamocortical Networks Cumulatively Reduces Cortical Correlation to Sensory Inputs.eNeuro · 2026Article
- A hierarchical electrical synaptic circuit mechanism for integrative parallel visual processing in the retina.Neuron · 2026Article
- Impact of Aii Amacrine Cell Rewiring in a Pathoconnectome-Based Computational Model of Early Retinal Degeneration.bioRxiv : the preprint server for biology · 2026Article
- Photomapping electrically coupled networks of the mature thalamus and cortex.bioRxiv : the preprint server for biology · 2026Article
- Article
- Activation of Dopamine D1 Receptors at the Axon Initial Segment-Like Process of Retinal AII Amacrine Cells Modulates Action Potential Firing.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Simulation of Conducted Responses in Microvascular Networks: Role of Gap Junction Current Rectification.Microcirculation (New York, N.Y. : 1994) · 2025Article
- Capacitance Measurements of Exocytosis From AII Amacrine Cells in Retinal Slices.Bio-protocol · 2025Article
- Retinal bipolar cells borrow excitability from electrically coupled inhibitory interneurons to amplify excitatory synaptic transmission.bioRxiv : the preprint server for biology · 2024Article
- Characterization of Retinal VIP-Amacrine Cell Development During the Critical Period.Cellular and molecular neurobiology · 2024Article
- Layers of inhibitory networks shape receptive field properties of AII amacrine cells.Cell reports · 2023Article
- Sensory deprivation arrests cellular and synaptic development of the night-vision circuitry in the retina.Current biology : CB · 2023Article
- Starburst amacrine cells form gap junctions in the early postnatal stage of the mouse retina.Frontiers in cellular neuroscience · 2023Article
- Functional properties of GABAFrontiers in ophthalmology · 2023Article
- Calcium-permeable AMPA receptors on AII amacrine cells mediate sustained signaling in the On-pathway of the primate retina.Cell reports · 2022Article
- The mosaic of AII amacrine cell bodies in rat retina is indistinguishable from a random distribution.Visual neuroscience · 2022Article
- Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals.eLife · 2022Article
- Dendritic Morphology of an Inhibitory Retinal Interneuron Enables Simultaneous Local and Global Synaptic Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
26 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the retina, AII (rod) amacrine cells are essential for integrating rod signals into the cone pathway. In addition to being interconnected via homologous gap junctions, these cells make extensive heterologous gap junctions with ON-cone bipolar cells (BCs). These gap junctions are the pathway for transfer of rod signals to the ON-system. To investigate the functional properties of these gap junctions, we performed simultaneous whole-cell recordings from pairs of AII amacrine cells and ON-cone bipolar cells in the in vitro slice preparation of the rat retina. We demonstrate strong electrical coupling with symmetrical junction conductance (approximately 1.2 nS) and very low steady-state voltage sensitivity. However, signal transmission is more effective in the direction from AII amacrine cells to ON-cone bipolar cells than in the other direction. This functional rectification can be explained by a corresponding difference in membrane input resistance between the two cell types. Signal transmission has low-pass filter characteristics with increasing attenuation and phase shift for increasing stimulus frequency. Action potentials in AII amacrine cells evoke distinct electrical postsynaptic potentials in ON-cone bipolar cells. Strong and temporally precise synchronization of subthreshold membrane potential fluctuations are commonly observed.
Indexed as
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12486148PMC6758447W1958948484What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.