ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2002
Presynaptic Ca2+ entry is unchanged during hippocampal mossy fiber long-term potentiation.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 55 citations in OpenAlex.
- Increased vesicle fusion competence underlies long-term potentiation at hippocampal mossy fiber synapses.Science advances · 2023Article
- Mechanistic insights into cAMP-mediated presynaptic potentiation at hippocampal mossy fiber synapses.Frontiers in cellular neuroscience · 2023Review
- Glycine Release Is Potentiated by cAMP via EPAC2 and CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Rapid CaProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Kainate Receptor-Mediated Depression of Glutamate Release Involves Protein Kinase A in the Cerebellum.International journal of molecular sciences · 2019Article
- Cerebellar Kainate Receptor-Mediated Facilitation of Glutamate Release Requires CaFrontiers in molecular neuroscience · 2018Article
- Non-canonical Mechanisms of Presynaptic Kainate Receptors Controlling Glutamate Release.Frontiers in molecular neuroscience · 2018Review
- Presynaptic long-term plasticity.Frontiers in synaptic neuroscience · 2013Review
- Presynaptic LTP and LTD of excitatory and inhibitory synapses.Cold Spring Harbor perspectives in biology · 2012Review
- Vesicular zinc promotes presynaptic and inhibits postsynaptic long-term potentiation of mossy fiber-CA3 synapse.Neuron · 2011Article
- Article
- Target-cell-dependent plasticity within the mossy fibre-CA3 circuit reveals compartmentalized regulation of presynaptic function at divergent release sites.The Journal of physiology · 2008Review
- Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Active zones for presynaptic plasticity in the brain.Molecular psychiatry · 2005Review
- Presynaptic kainate receptor facilitation of glutamate release involves protein kinase A in the rat hippocampus.The Journal of physiology · 2004Article
- Photolysis of postsynaptic caged Ca2+ can potentiate and depress mossy fiber synaptic responses in rat hippocampal CA3 pyramidal neurons.Journal of neurophysiology · 2004Article
- Calcium influx through hyperpolarization-activated cation channels (I(h) channels) contributes to activity-evoked neuronal secretion.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampal mossy fiber (MF)-CA3 synapse exhibits NMDA receptor-independent long-term potentiation (LTP), which is expressed by presynaptic mechanisms leading to persistent enhancement of transmitter release. Recent studies have identified several molecules that may play an important role in MF-LTP. These include Rab3A, RIM1alpha, kainate autoreceptor, and hyperpolarization-activated cation channel (I(h)). However, the precise cellular expression mechanism remains to be determined because some studies noticed essential roles of release machinery molecules, whereas others suggested modulation of the ionotropic processes affecting Ca2+ entry into the presynaptic terminals. Using fluorescence recordings of presynaptic Ca2+ in hippocampal slices, here we demonstrated that MF-LTP is not accompanied by an increase in presynaptic Ca2+ influx during an action potential. Whole-cell recordings from CA3 neurons revealed long-lasting increases in mean frequency, but not mean amplitude, of miniature EPSCs after the high-frequency stimulation of MFs. These data indicate that the presynaptic expression mechanisms responsible for enhanced transmitter release during MF-LTP involve persistent modification of presynaptic molecular targets residing downstream of Ca2+ entry.
Indexed as
Identifiers
12486143PMC6758426W2104085813What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.