ArticleGenes to cells : devoted to molecular & cellular mechanisms2002
A comparative cDNA microarray analysis reveals a spectrum of genes regulated by Pax6 in mouse lens.
Article in Genes to cells : devoted to molecular & cellular mechanisms, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- Transcriptome Meta-Analysis Uncovers Cell-Specific Regulatory Relationships in Embryonic, Juvenile, Adult, and Aged Mouse Lens Epithelium and Fibers.Investigative ophthalmology & visual science · 2025Pooled it
- Integrated single-cell multiomics uncovers foundational regulatory mechanisms of lens development and pathology.Development (Cambridge, England) · 2024Article
- RNA sequencing-based transcriptomic profiles of embryonic lens development for cataract gene discovery.Human genetics · 2018Article
- Transcription factor PAX6 as a novel prognostic factor and putative tumour suppressor in non-small cell lung cancer.Scientific reports · 2018Article
- Requirement ofRoyal Society open science · 2017Article
- Systems biology of lens development: A paradigm for disease gene discovery in the eye.Experimental eye research · 2017Review
- Congenital aniridia: etiology, manifestations and management.Expert review of ophthalmology · 2016Article
- Contact-mediated control of radial migration of corneal epithelial cells.Molecular vision · 2016Article
- Lens crystallin modifications and cataract in transgenic mice overexpressing acylpeptide hydrolase.The Journal of biological chemistry · 2014Article
- Ocular surface development and gene expression.Journal of ophthalmology · 2013Article
- Genome-wide microarray comparison reveals downstream genes of Pax6 in the developing mouse cerebellum.The European journal of neuroscience · 2012Article
- RGMA and neogenin protein expression are influenced by lens injury following optic nerve crush in the rat retina.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2012Article
- 3T3 cell lines stably expressing Pax6 or Pax6(5a)--a new tool used for identification of common and isoform specific target genes.PloS one · 2012Article
- Effects of elevated Pax6 expression and genetic background on mouse eye development.Investigative ophthalmology & visual science · 2009Article
- Molecule-level imaging of Pax6 mRNA distribution in mouse embryonic neocortex by molecular interaction force microscopy.Nucleic acids research · 2009Article
- PAX6 dosage effects on corneal development, growth, and wound healing.Developmental dynamics : an official publication of the American Association of Anatomists · 2008Article
- Differential requirements for the Pax6(5a) genes eyegone and twin of eyegone during eye development in Drosophila.Developmental biology · 2008Article
- Genetic and epigenetic mechanisms of gene regulation during lens development.Progress in retinal and eye research · 2007Review
- Positive autoregulation of the transcription factor Pax6 in response to increased levels of either of its major isoforms, Pax6 or Pax6(5a), in cultured cells.BMC developmental biology · 2006Article
- Regulation of alphaA-crystallin via Pax6, c-Maf, CREB and a broad domain of lens-specific chromatin.The EMBO journal · 2006Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundPax6 is a transcription factor that is required for induction, growth, and maintenance of the lens; however, few direct target genes of Pax6 are known.
resultsIn this report, we describe the results of a cDNA microarray analysis of lens transcripts from transgenic mice over-expressing Pax6 in lens fibre cells in order to narrow the field of potential direct Pax6 target genes. This study revealed that the transcript levels were significantly altered for 508 of the 9700 genes analysed, including five genes encoding the cell adhesion molecules beta1-integrin, JAM1, L1 CAM, NCAM-140 and neogenin. Notably, comparisons between the genes differentially expressed in Pax6 heterozygous and Pax6 over-expressing lenses identified 13 common genes, including paralemmin, GDIbeta, ATF1, Hrp12 and Brg1. Immunohistochemistry and Western blotting demonstrated that Brg1 is expressed in the embryonic and neonatal (2-week-old) but not in 14-week adult lenses, and confirmed altered expression in transgenic lenses over-expressing Pax6. Furthermore, EMSA demonstrated that the BRG1 promoter contains Pax6 binding sites, further supporting the proposition that it is directly regulated by Pax6.
conclusionsThese results provide a list of genes with possible roles in lens biology and cataracts that are directly or indirectly regulated by Pax6.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.