ReviewTexas Heart Institute journal2002
Cellular precursors of the coronary arteries.
Review in Texas Heart Institute journal, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 60 citations in OpenAlex.
- The Formation of Coronary Vessels in Cardiac Development and Disease.Cold Spring Harbor perspectives in biology · 2020Review
- Hypoxia Supports Epicardial Cell Differentiation in Vascular Smooth Muscle Cells through the Activation of the TGFβ Pathway.Journal of cardiovascular development and disease · 2018Article
- Case report: a common trunk of the coronary arteries.Surgical and radiologic anatomy : SRA · 2017Article
- Signaling pathways that control rho kinase activity maintain the embryonic epicardial progenitor state.The Journal of biological chemistry · 2015Article
- Cellular origin and developmental program of coronary angiogenesis.Circulation research · 2015Review
- The clinical anatomy of the coronary arteries.Journal of cardiovascular translational research · 2013Review
- Engineered myocardial tissues constructed in vivo using cardiomyocyte-like cells derived from bone marrow mesenchymal stem cells in rats.Journal of biomedical science · 2012Article
- Cardiac regeneration from activated epicardium.PloS one · 2012Article
- Plakophilin-2 and the migration, differentiation and transformation of cells derived from the epicardium of neonatal rat hearts.Cell communication & adhesion · 2011Article
- Expression of lymphatic markers during avian and mouse cardiogenesis.Anatomical record (Hoboken, N.J. : 2007) · 2010Article
- Connexin 43 regulates epicardial cell polarity and migration in coronary vascular development.Development (Cambridge, England) · 2009Article
- Coronary vessel development and insight towards neovascular therapy.International journal of experimental pathology · 2009Review
- New morphological aspects of blood islands formation in the embryonic mouse hearts.Histochemistry and cell biology · 2009Article
- Coronary endothelial proliferation and morphogenesis are regulated by a VEGF-mediated pathway.Developmental dynamics : an official publication of the American Association of Anatomists · 2009Article
- Congenital coronary arteries anomalies: review of the literature and multidetector computed tomography (MDCT)-appearance.Surgical and radiologic anatomy : SRA · 2007Review
- Signals from both sides: Control of cardiac development by the endocardium and epicardium.Seminars in cell & developmental biology · 2007Review
- Coronary artery anomalies. Part I: Recent insights from molecular embryology.Zeitschrift fur Kardiologie · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coronary vessels develop from a primary vascular network that differentiates in the subepicardium through a process of vasculogenesis, that is, self-assembly of mesenchymal vascular progenitors. Further growth of the subepicardial vascular plexus through a complex process of angiogenesis, vascular remodeling, and arterialization of specific branches gives rise to the definitive coronary system. This report is intended to summarize current knowledge on the origin of the coronary vascular progenitors and to provide new insights suggested by recent findings. It has been established that the mesenchymal precursors of the vascular smooth muscle cells and the adventitial fibroblasts originate from an epithelial-mesenchymal transformation of the epicardial mesothelium. We report herein experimental evidence that the precursors of the coronary endothelium are also epicardium-derived cells (EPDCs). The evidence shown includes co-localization of mesothelial and endothelial molecular markers as well as cell lineage studies performed through direct labeling of the epicardial cells. If this proposal is confirmed, the early EPDCs might be found to have a competence similar to that shown by the recently discovered bipotential vascular progenitor cells, which are able to differentiate into endothelium or smooth muscle depending on their exposure to VEGF or PDGF-BB. It is conceivable that the earliest EPDCs differentiate into endothelial cells in response to myocardially secreted VEGF, while subsequent EPDCs, recruited by the nascent capillaries via PDGFRbeta signaling, differentiate into percytes and smooth muscle cells.
Indexed as
Identifiers
12484607PMC140285W1453493201What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.