ArticleOncogene2002
Modulation of cystatin C expression impairs the invasive and tumorigenic potential of human glioblastoma cells.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 73 citations in OpenAlex.
- Article
- pH-dependent and dynamic interactions of cystatin C with heparan sulfate.Communications biology · 2021Article
- Cold-inducible RNA binding protein promotes breast cancer cell malignancy by regulating Cystatin C levels.RNA (New York, N.Y.) · 2021Article
- Transformation Foci in IDH1-mutated Gliomas Show STAT3 Phosphorylation and Downregulate the Metabolic Enzyme ETNPPL, a Negative Regulator of Glioma Growth.Scientific reports · 2020Article
- Utility of cystatin C as a potential bladder tumour biomarker confirmed by surface plasmon resonance technique.The Indian journal of medical research · 2018Article
- Cystatin C deficiency suppresses tumor growth in a breast cancer model through decreased proliferation of tumor cells.Oncotarget · 2017Article
- Proteome and Secretome Characterization of Glioblastoma-Derived Neural Stem Cells.Stem cells (Dayton, Ohio) · 2017Article
- TRAIL DR5-CTSB crosstalk participates in breast cancer autophagy initiated by SAHA.Cell death discovery · 2017Article
- Clinical significance of serum cathepsin B and cystatin C levels and their ratio in the prognosis of patients with esophageal cancer.OncoTargets and therapy · 2017Article
- Monocyte-derived macrophage assisted breast cancer cell invasion as a personalized, predictive metric to score metastatic risk.Scientific reports · 2015Article
- Expression of cystatin C and its effect on EC9706 cells in esophageal carcinoma.International journal of clinical and experimental pathology · 2015Article
- Clinical significance of CD146 and latexin during different stages of thyroid cancer.Molecular and cellular biochemistry · 2013Article
- Cathepsin B as a cancer target.Expert opinion on therapeutic targets · 2013Review
- Epigenetic regulation of cathepsin L expression in chronic myeloid leukaemia.Journal of cellular and molecular medicine · 2011Article
- Article
- Post-translational regulation of cathepsin B, but not of other cysteine cathepsins, contributes to increased glioblastoma cell invasiveness in vitro.Pathology oncology research : POR · 2009Article
- Article
- Proteinases and their inhibitors in liver cancer.World journal of hepatology · 2009Article
- Frequent loss of cystatin E/M expression implicated in the progression of prostate cancer.Oncogene · 2009Article
- Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas.Laboratory investigation; a journal of technical methods and pathology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
Abstract
Increases in the abundance of cathepsin B transcript and protein with increased tumor grade and changes in subcellular localization and activity of this enzyme. We observed progressive reductions in levels of the protease inhibitor cystatin C, an inhibitor of cathepsin B with corresponding increases in the malignancy of glioma cell lines, implying an inverse correlation between cystatin C and tumor grade. To investigate the role of cystatin C in the invasion of brain tumor cells, we stably transfected SNB19 glioblastoma cells with either a 0.4-kb cDNA construct of human cystatin C in the sense orientation or an empty vector. Clones expressing sense-cystatin C cDNA had higher cystatin C mRNA and protein levels than did control cells. Sense-transfected cells were also markedly less invasive than control cells in a Matrigel invasion assay and in a coculture assay of SNB19 spheroids and fetal rat brain aggregates. Finally, the sense-transfected cells did not form tumors in nude mice upon intracerebral injection. These results strongly implicate cystatin C in the invasiveness of human glioblastoma cells and suggest that sense transcripts of cystatin C may prove useful in cancer therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.