ArticleMolecular and cellular biology2003
Carcinoembryonic antigen-related cell adhesion molecule 10 expressed specifically early in pregnancy in the decidua is dispensable for normal murine development.
Article in Molecular and cellular biology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 20 citations in OpenAlex.
- Dampened HPG axis activity and altered ovarian gene transcription in Dummerstorf high-fertility mouse line FL2.Endocrine connections · 2026Article
- Physiological functions of seminal vesicle secretions in male fertility.Histology and histopathology · 2026Review
- Conservation at the uterine-placental interface.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Maternal oxycodone treatment causes pathophysiological changes in the mouse placenta.Placenta · 2020Article
- Large-scale discovery of male reproductive tract-specific genes through analysis of RNA-seq datasets.BMC biology · 2020Article
- Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7.Nature communications · 2015Article
- Genetic analysis of litter size in mice.The Journal of veterinary medical science · 2015Article
- Increased osteoclastogenesis in mice lacking the carcinoembryonic antigen-related cell adhesion molecule 1.PloS one · 2014Article
- The genome-defence gene Tex19.1 suppresses LINE-1 retrotransposons in the placenta and prevents intra-uterine growth retardation in mice.Human molecular genetics · 2013Article
- Widespread divergence of the CEACAM/PSG genes in vertebrates and humans suggests sensitivity to selection.PloS one · 2013Article
- Loss of mammal-specific tectorial membrane component carcinoembryonic antigen cell adhesion molecule 16 (CEACAM16) leads to hearing impairment at low and high frequencies.The Journal of biological chemistry · 2012Article
- Coevolution of activating and inhibitory receptors within mammalian carcinoembryonic antigen families.BMC biology · 2010Article
- Demonstration of a glycoprotein derived from the Ceacam10 gene in mouse seminal vesicle secretions.Biology of reproduction · 2005Article
- Structure and evolution of the mouse pregnancy-specific glycoprotein (Psg) gene locus.BMC genomics · 2005Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The carcinoembryonic antigen (CEA) family consists of a large group of evolutionarily and structurally divergent glycoproteins. The murine CEACAM9 and CEACAM11-related proteins as well as the pregnancy-specific glycoproteins (PSG) are secreted members of the CEA family which are differentially expressed in fetal trophoblast cell populations during placental development. PSG are essential for a successful pregnancy, possibly by protecting the semiallotypic fetus from the maternal immune system. In contrast, Ceacam10 mRNA, coding for a protein identical in structure with CEACAM11-related proteins, is expressed in the maternal decidua surrounding the implantation site of the conceptus only during early stages of gestation between day 6.5 and day 10.5 postcoitum. To determine its role during murine development, we inactivated Ceacam10. Ceacam10(-/-) mice developed, like the previously established Ceacam9(-/-) mice, indistinguishably from wild-type littermates with respect to sex ratio, weight gain, and fertility. However, a small but significant reduction of the litter size by 23% was observed in Ceacam10(-/-) matings. Furthermore, combining the Ceacam9 and Ceacam10 null alleles, both located on chromosome 7, by meiotic recombination and subsequent mating of heterozygotes carrying both knockout alleles on one chromosome yielded wild-type and double knockout offspring at the expected Mendelian ratio. Taken together, both Ceacam10 and Ceacam9, alone or in combination, are not essential for either murine placental and embryonic development or for adult life.
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