Trial reportAIDS (London, England)2003
The effect of rapid HIV-1 testing on uptake of perinatal HIV-1 interventions: a randomized clinical trial.
Trial report in AIDS (London, England), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Pooled it
- Pooled it
- Uptake of workplace HIV counselling and testing: a cluster-randomised trial in Zimbabwe.PLoS medicine · 2006Trial
- Point-of-Care HIV Viral Load Testing: an Essential Tool for a Sustainable Global HIV/AIDS Response.Clinical microbiology reviews · 2019Review
- Effect of Point-of-Care Diagnostics on Maternal Outcomes in Human Immunodeficiency Virus-Infected Women: Systematic Review and Meta-analysis.Point of care · 2017Article
- Challenges in the delivery of public HIV testing and counselling (HTC) in Douala, Cameroon: providers perspectives and implications on quality of HTC services.BMC international health and human rights · 2017Article
- Impact of point-of-care diagnostics on maternal outcomes in HIV-infected women: systematic review and meta-analysis protocol.BMJ open · 2016Article
- Returning for HIV Test Results: A Systematic Review of Barriers and Facilitators.International scholarly research notices · 2016Review
- The evaluation of accuracy of serial rapid HIV test algorithm in the diagnosis of HIV antibodies among pregnant women in south east Nigeria.BMC research notes · 2015Article
- Barriers to Implementation of Rapid and Point-of-Care Tests for Human Immunodeficiency Virus Infection: Findings From a Systematic Review (1996-2014).Point of care · 2015Article
- A review of Human Immunodeficiency Virus (HIV) rapid testing.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2014Article
- Diagnostic point-of-care tests in resource-limited settings.The Lancet. Infectious diseases · 2014Review
- Perspectives on introduction and implementation of new point-of-care diagnostic tests.The Journal of infectious diseases · 2012Article
- A Quality Management Approach to Implementing Point-of-Care Technologies for HIV Diagnosis and Monitoring in Sub-Saharan Africa.Journal of tropical medicine · 2012Article
- Factors associated with HIV testing history and HIV-test result follow-up among female sex workers in two cities in Yunnan, China.Sexually transmitted diseases · 2011Article
- Advances in prevention of mother-to-child HIV transmission: the international perspectives.Indian journal of pediatrics · 2011Review
- Antiretroviral therapy initiated soon after HIV diagnosis as standard care: potential to save lives?HIV/AIDS (Auckland, N.Z.) · 2011Article
- Indeterminate rapid HIV-1 test results among antenatal and postnatal mothers.International journal of STD & AIDS · 2009Article
- Loss to follow-up of adults in public HIV care systems in central Mozambique: identifying obstacles to treatment.Journal of acquired immune deficiency syndromes (1999) · 2009Article
- Preventing mother-to-child transmission of HIV in resource-limited settings: the Elizabeth Glaser Pediatric AIDS Foundation experience.American journal of public health · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
Abstract
objectiveWe examined whether HIV-1 testing using a rapid assay increases the proportion of pregnant women obtaining HIV-1 results and the uptake of perinatal HIV-1 interventions.
methodsPregnant women attending public health clinics in Nairobi were offered voluntary counselling and testing for HIV-1. Consenting women were randomly assigned to receive either rapid or conventional HIV-1 testing. Women randomly assigned to rapid testing were allowed to receive same-day results or to return later. The results for women randomly assigned to conventional enzyme-linked immunosorbent assay (ELISA) testing were available after 7 days. HIV-1-infected women were referred for antiretroviral prophylaxis to prevent mother-to-child transmission of HIV-1.
resultsAmong 1282 women offered voluntary HIV-1 testing and counselling, 1249 accepted testing, of whom 627 were randomly assigned to rapid testing and 622 to conventional testing. The median duration between testing and obtaining results was 0 days for women who received rapid testing compared with 11 days for women who received conventional testing. The percentage receiving HIV-1 results was significantly higher among women who received rapid testing compared with conventional testing. Of 161 HIV-1-seropositive women, only 24 received antiretroviral prophylaxis. The uptake of perinatal HIV-1 interventions did not differ between HIV-1-seropositive women randomly assigned to rapid testing or conventional ELISA testing.
conclusionRapid HIV-1 testing significantly increased the proportion of women receiving HIV-1 results, which is important for sexual and perinatal HIV-1 prevention. The challenge remains to improve the uptake of perinatal HIV-1 interventions among HIV-1-seropositive women.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.