ArticleProceedings of the National Academy of Sciences of the United States of America2002
An ensemble method for identifying regulatory circuits with special reference to the qa gene cluster of Neurospora crassa.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.
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Who cites it
52 citing papers in PubMed, 118 citations in OpenAlex.
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- SAND: Automated Time-Domain Modeling of NMR Spectra Applied to Metabolite Quantification.Analytical chemistry · 2024Article
- The macroscopic limit to synchronization of cellular clocks in single cells of Neurospora crassa.Scientific reports · 2022Article
- Current Approaches of Building Mechanistic Pharmacodynamic Drug-Target Binding Models.Methods in molecular biology (Clifton, N.J.) · 2022Article
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- Identifying a stochastic clock network with light entrainment for single cells of Neurospora crassa.Scientific reports · 2020Article
- Unravelling the γ-butyrolactone network in Streptomyces coelicolor by computational ensemble modelling.PLoS computational biology · 2020Article
- Modeling differentiation-state transitions linked to therapeutic escape in triple-negative breast cancer.PLoS computational biology · 2019Article
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- Bayesian Parameter Identification for Turing Systems on Stationary and Evolving Domains.Bulletin of mathematical biology · 2019Article
- Modeling the interactions of sense and antisense Period transcripts in the mammalian circadian clock network.PLoS computational biology · 2018Article
- Ensemble methods for stochastic networks with special reference to the biological clock of Neurospora crassa.PloS one · 2018Article
- The best models of metabolism.Wiley interdisciplinary reviews. Systems biology and medicine · 2017Review
- Mathematical model reveals role of nucleotide signaling in airway surface liquid homeostasis and its dysregulation in cystic fibrosis.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- JuPOETs: a constrained multiobjective optimization approach to estimate biochemical model ensembles in the Julia programming language.BMC systems biology · 2017Article
- Synchronizing stochastic circadian oscillators in single cells of Neurospora crassa.Scientific reports · 2016Article
- The inflammatory response to influenza A virus (H1N1): An experimental and mathematical study.Journal of theoretical biology · 2015Article
- A Bayesian active learning strategy for sequential experimental design in systems biology.BMC systems biology · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A chemical reaction network for the regulation of the quinic acid (qa) gene cluster of Neurospora crassa is proposed. An efficient Monte Carlo method for walking through the parameter space of possible chemical reaction networks is developed to identify an ensemble of deterministic kinetics models with rate constants consistent with RNA and protein profiling data. This method was successful in identifying a model ensemble fitting available RNA profiling data on the qa gene cluster.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.