ArticleJournal of virology2003
Identification and characterization of a new class of human immunodeficiency virus type 1 recombinants comprised of two circulating recombinant forms, CRF07_BC and CRF08_BC, in China.
Article in Journal of virology, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- HIV-1 genetic diversity and pretreatment drug resistance in Xishuangbanna, a China-Myanmar-Laos border region.BMC infectious diseases · 2026Article
- Molecular analysis of multiple HIV-1 BC recombinant strains circulating worldwide shows predominance of the C genotype in the viral genomic structure.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Unraveling HIV-1 transmission patterns through molecular surveillance in a hotspot in Yunnan Province, China.Scientific reports · 2025Article
- Exploring and Predicting the Drivers of Ongoing HIV-1 Transmission in Guangyuan, Sichuan.Infection and drug resistance · 2023Article
- The characteristics of HIV-1 subtype B on phylogenetic dynamic and molecular transmission network in Fuyang City, China, 2011 to 2019.Frontiers in public health · 2023Article
- Characterization of HIV-1 molecular epidemiology and transmitted drug-resistance in newly diagnosed HIV-infected patients in Sichuan, China.BMC infectious diseases · 2022Article
- Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China.BMC infectious diseases · 2021Article
- Comparative Circulation Dynamics of the Five Main HIV Types in China.Journal of virology · 2020Article
- Premature Stop Codon at Residue 101 within HIV-1 Rev Does Not Influence Viral Replication of Clade BC but Severely Reduces Viral Fitness of Clade B.Virologica Sinica · 2020Article
- First description of two new HIV-1 recombinant forms CRF82_cpx and CRF83_cpx among drug users in Northern Myanmar.Virulence · 2017Article
- First Appearance of HIV-1 CRF07_BC and CRF08_BC Outside China.AIDS research and human retroviruses · 2017Article
- Genome sequence of a novel HIV-1 circulating recombinant form (CRF64_BC) identified from Yunnan, China.AIDS research and human retroviruses · 2014Article
- Identification of a novel HIV-1 circulating recombinant form (CRF62_BC) in western Yunnan of China.AIDS research and human retroviruses · 2014Article
- Genome sequence of a novel HIV-1 circulating recombinant form (CRF57_BC) identified from Yunnan, China.AIDS research and human retroviruses · 2014Article
- Near full-length genome sequence of a novel HIV type 1 second-generation recombinant form (CRF01_AE/CRF07_BC) identified among men who have sex with men in Jilin, China.AIDS research and human retroviruses · 2013Article
- Current Trends of HIV Recombination Worldwide.Infectious disease reports · 2013Review
- Construction and characterization of highly infectious full-length molecular clones of a HIV-1 CRF07_BC isolate from Xinjiang, China.PloS one · 2013Article
- Emerging variability in HIV-1 genetics among recently infected individuals in Yunnan, China.PloS one · 2013Article
- Genetic architecture of HIV-1 genes circulating in north India & their functional implications.The Indian journal of medical research · 2011Review
- Sequence analysis of the gag-pol gene of human immunodeficiency virus type 1 of intersubtype (B'/C) recombinant strain in Beijing, China.AIDS research and human retroviruses · 2011Article
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Authors and funding
6 authors.
Funding
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Abstract
We identified a new class of human immunodeficiency virus type 1 (HIV-1) recombinants (00CN-HH069 and 00CN-HH086) in which further recombination occurred between two established circulating recombinant forms (CRFs). These two isolates were found among 57 HIV-1 samples from a cohort of injecting drug users in eastern Yunnan Province of China. Informative-site analysis in conjunction with bootscanning plots and exploratory tree analysis revealed that these two strains were closely related mosaics comprised of CRF07_BC and CRF08_BC, which are found in China. The genotype screening based on gag-reverse transcriptase sequences of 57 samples from eastern Yunnan identified 47 CRF08_BC specimens (82.5%), 5 CRF07_BC specimens (8.8%), and 3 additional specimens with the novel recombinant structure. These new "second-generation" recombinants thus constitute a substantial proportion (5 of 57; 8.8%) of HIV-1 strains in this population and may belong to a new but yet-undefined class of CRF. This might be the first example of CRFs recombining with each other, leading to the evolution of second-generation inter-CRF recombinants.
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