ArticleEukaryotic cell2002
Loss of compartmentalization causes misregulation of lysine biosynthesis in peroxisome-deficient yeast cells.
Article in Eukaryotic cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Research progress on metabolic engineering for efficient squalene synthesis in yeast cell factories.Biotechnology letters · 2026Review
- Peroxisome deficiency impacts metabolites of lysine, lipid, and polyamine metabolism in Saccharomyces cerevisiae.Histochemistry and cell biology · 2026Article
- Integrative Omics reveals changes in the cellular landscape of peroxisome-deficientMicrobial cell (Graz, Austria) · 2025Article
- Proteins that carry dual targeting signals can act as tethers between peroxisomes and partner organelles.PLoS biology · 2024Article
- Peroxisomal compartmentalization of amino acid biosynthesis reactions imposes an upper limit on compartment size.Nature communications · 2023Article
- Article
- Compartmentalization engineering of yeasts to overcome precursor limitations and cytotoxicity in terpenoid production.Frontiers in bioengineering and biotechnology · 2023Review
- The biochemical basis of mitochondrial dysfunction in Zellweger Spectrum Disorder.EMBO reports · 2021Article
- Transforming yeast peroxisomes into microfactories for the efficient production of high-value isoprenoids.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Two NAD-linked redox shuttles maintain the peroxisomal redox balance in Saccharomyces cerevisiae.Scientific reports · 2017Article
- Human gene correlation analysis (HGCA): a tool for the identification of transcriptionally co-expressed genes.BMC research notes · 2012Article
- Regulation of amino acid, nucleotide, and phosphate metabolism in Saccharomyces cerevisiae.Genetics · 2012Article
- Novel and simple transformation algorithm for combining microarray data sets.BMC bioinformatics · 2007Article
- An attempt for combining microarray data sets by adjusting gene expressions.Cancer research and treatment · 2007Article
- A peroxisomal glutathione transferase of Saccharomyces cerevisiae is functionally related to sulfur amino acid metabolism.Eukaryotic cell · 2006Article
- Coping with polychlorinated biphenyl (PCB) toxicity: Physiological and genome-wide responses of Burkholderia xenovorans LB400 to PCB-mediated stress.Applied and environmental microbiology · 2006Article
- Heterologous expression implicates a GATA factor in regulation of nitrogen metabolic genes and ion homeostasis in the halotolerant yeast Debaryomyces hansenii.Eukaryotic cell · 2006Article
- Coordinate regulation of multiple and distinct biosynthetic pathways by TOR and PKA kinases in S. cerevisiae.Current genetics · 2006Article
- Uptake of the beta-lactam precursor alpha-aminoadipic acid in Penicillium chrysogenum is mediated by the acidic and the general amino acid permease.Applied and environmental microbiology · 2004Article
- Coexpression analysis of human genes across many microarray data sets.Genome research · 2004Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
To characterize the metabolic role of peroxisomes in yeast cells under physiological conditions, we performed a comprehensive meta-analysis of published microarray data. Previous studies of yeast peroxisomes have mainly been focused on the function of peroxisomes under extreme conditions, such as growth on oleate or methanol as the sole carbon source, and may therefore not be representative of the normal physiological role of yeast peroxisomes. Surprisingly, our analysis of the microarray data reveals that the only pathway responding to peroxisome deficiency in mid-log phase is lysine biosynthesis, whereas classical peroxisomal pathways such as beta-oxidation are unaffected. We show that the upregulation of lysine biosynthesis genes in peroxisome-deficient yeasts shares many characteristics with the physiological response to lysine starvation. We provide data that suggest that this is the result of a "pathological" stimulation of the Lys14p transcriptional activator by the pathway intermediate aminoadipate semialdehyde. Mistargeting of the peroxisomal lysine pathway to the cytosol increases the active concentration of aminoadipate semialdehyde, which is no longer contained in the peroxisome and can now activate Lys14p at much lower levels than in wild-type yeasts. This is the first well-documented example of pathway misregulation in response to peroxisome deficiency and will be useful in understanding the phenotypic details of human peroxisome-deficient patients (Zellweger syndrome).
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