ArticleGut2003
Association between K469E allele of intercellular adhesion molecule 1 gene and inflammatory bowel disease in a Japanese population.
Article in Gut, 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Characteristics of Japanese inflammatory bowel disease susceptibility loci.Journal of gastroenterology · 2014Pooled it
- Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical trial of antisense to ICAM-1.Clinical and experimental immunology · 2005Trial
- Association between two single base polymorphisms of intercellular adhesion molecule 1 gene and inflammatory bowel disease.Gastroenterology and hepatology from bed to bench · 2016Article
- Serum intercellular adhesion molecule 1 variations in young children with acute otitis media.Clinical and vaccine immunology : CVI · 2010Article
- Intercellular adhesion molecule-1 gene K469E polymorphism and ischemic stroke: a case-control study in a Chinese population.Molecular biology reports · 2009Article
- ICAM-1 (Lys469Glu) and PECAM-1 (Leu125Val) polymorphisms in diffuse astrocytomas.Clinical and experimental medicine · 2009Article
- Variations in host genes encoding adhesion molecules and susceptibility to falciparum malaria in India.Malaria journal · 2008Article
- Novel association of ABO histo-blood group antigen with soluble ICAM-1: results of a genome-wide association study of 6,578 women.PLoS genetics · 2008Article
- Genetic factors associated with the development of inflammatory bowel disease.World journal of gastroenterology · 2007Review
- Rheostat regulation of integrin-mediated leukocyte adhesion.The Journal of clinical investigation · 2007Article
- Article
- Intercellular adhesion molecule 1 gene polymorphisms do not contribute to Graves' disease in Chinese patients.Endocrine · 2007Article
- Relation between common polymorphisms in genes related to inflammatory response and colorectal cancer.World journal of gastroenterology · 2006Article
- NOD2/CARD15, NOD1/CARD4, and ICAM-1 gene polymorphisms in Turkish patients with inflammatory bowel disease.Journal of gastroenterology · 2006Article
- Current concept on the pathogenesis of inflammatory bowel disease-crosstalk between genetic and microbial factors: pathogenic bacteria and altered bacterial sensing or changes in mucosal integrity take "toll" ?World journal of gastroenterology · 2006Review
- There is no association between K469E ICAM-1 gene polymorphism and biliary atresia.World journal of gastroenterology · 2005Article
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12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
aimsThe genetic contribution to inflammatory bowel disease (IBD) is under investigation. Recent evidence indicates a significant linkage between a locus on chromosome 19p13 and IBD. We investigated the association between an intercellular adhesion molecule 1 gene (ICAM-1) polymorphism located on chromosome 19p13 and IBD in a Japanese population.
methodsWe compared 207 Japanese patients who had IBD (79 with Crohn's disease (CD); 128 with ulcerative colitis (UC)) with 103 unrelated Japanese controls. We determined R241G and K469E polymorphisms of the ICAM-1 gene using polymerase chain reaction (PCR) techniques.
resultsBoth frequency and carriage rate of the K469 allele were significantly higher in IBD patients than in controls (allelic frequency, p(c)=0.0026; carriage rate, p(c)=0.0034; odds ratio 2.59; 95% confidence interval 1.42-4.68). Furthermore, the frequency of the K469 allele was significantly increased in both CD and UC. Subgroup analysis demonstrated that both K469 allelic frequency and K469 carriage rate were significantly higher in patients with the small bowel and colon type of CD and entire colitis compared with healthy controls.
conclusionsWe identified an overall association between IBD and ICAM-1 K469 in a Japanese population. Further studies of this chromosome region are required to elucidate the gene responsible for IBD.
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