ArticleMolecular biology of the cell2002
A novel transforming growth factor-beta receptor-interacting protein that is also a light chain of the motor protein dynein.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 61 citations in OpenAlex.
- DYNLRB1 is essential for dynein mediated transport and neuronal survival.Neurobiology of disease · 2020Article
- km23-1/DYNLRB1 regulation of MEK/ERK signaling and R-Ras in invasive human colorectal cancer cells.Cell biology international · 2020Article
- Targeting mitotic pathways for endocrine-related cancer therapeutics.Endocrine-related cancer · 2017Review
- Signaling Receptors for TGF-β Family Members.Cold Spring Harbor perspectives in biology · 2016Review
- N-acetyl-D-glucosamine kinase interacts with dynein light-chain roadblock type 1 at Golgi outposts in neuronal dendritic branch points.Experimental & molecular medicine · 2015Article
- The genetics of splicing in neuroblastoma.Cancer discovery · 2015Article
- Association of eight EST-derived SNPs with carcass and meat quality traits in pigs.Journal of applied genetics · 2015Article
- The genome of the hydatid tapeworm Echinococcus granulosus.Nature genetics · 2013Article
- Requirement for protein kinase A in the phosphorylation of the TGFβ receptor-interacting protein km23-1 as a component of TGFβ downstream effects.Experimental cell research · 2013Article
- Decreased tumor progression and invasion by a novel anti-cell motility target for human colorectal carcinoma cells.PloS one · 2013Article
- A dynein motor attachment complex regulates TGFß/Smad3 signaling.International journal of biological sciences · 2013Article
- Role of km23-1 in RhoA/actin-based cell migration.Biochemical and biophysical research communications · 2012Article
- The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras.The Journal of biological chemistry · 2012Article
- Molecular cloning of the Robl gene from Bombyx mori and studies of its developmental and physicochemical regulation.Molecular biology reports · 2012Article
- Requirement of a dynein light chain in transforming growth factor β signaling in zebrafish ovarian follicle cells.Molecular and cellular endocrinology · 2012Article
- Overexpression of the dynein light chain km23-1 in human ovarian carcinoma cells inhibits tumor formation in vivo and causes mitotic delay at prometaphase/metaphase.International journal of cancer · 2011Article
- The crystal structure of dynein intermediate chain-light chain roadblock complex gives new insights into dynein assembly.The Journal of biological chemistry · 2010Article
- Dynein light intermediate chain in Aspergillus nidulans is essential for the interaction between heavy and intermediate chains.The Journal of biological chemistry · 2009Article
- Requirement of a dynein light chain in TGFbeta/Smad3 signaling.Journal of cellular physiology · 2009Article
- Identification of dynein light chain road block-1 as a novel interaction partner with the human reduced folate carrier.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
The phosphorylated, activated cytoplasmic domains of the transforming growth factor-beta (TGFbeta) receptors were used as probes to screen an expression library that was prepared from a highly TGFbeta-responsive intestinal epithelial cell line. One of the TGFbeta receptor-interacting proteins isolated was identified to be the mammalian homologue of the LC7 family (mLC7) of dynein light chains (DLCs). This 11-kDa cytoplasmic protein interacts with the TGFbeta receptor complex intracellularly and is phosphorylated on serine residues after ligand-receptor engagement. Forced expression of mLC7-1 induces specific TGFbeta responses, including an activation of Jun N-terminal kinase (JNK), a phosphorylation of c-Jun, and an inhibition of cell growth. Furthermore, TGFbeta induces the recruitment of mLC7-1 to the intermediate chain of dynein. A kinase-deficient form of TGFbeta RII prevents both mLC7-1 phosphorylation and interaction with the dynein intermediate chain (DIC). This is the first demonstration of a link between cytoplasmic dynein and a natural growth inhibitory cytokine. Furthermore, our results suggest that TGFbeta pathway components may use a motor protein light chain as a receptor for the recruitment and transport of specific cargo along microtublules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.