ArticleMolecular biology of the cell2002
Novel myosin heavy chain kinase involved in disassembly of myosin II filaments and efficient cleavage in mitotic dictyostelium cells.
Article in Molecular biology of the cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
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- Cell shape regulation through mechanosensory feedback control.Journal of the Royal Society, Interface · 2015Article
- Cell-scale dynamic recycling and cortical flow of the actin-myosin cytoskeleton for rapid cell migration.Biology open · 2013Article
- Myosin heavy chain kinases play essential roles in Ca2+, but not cAMP, chemotaxis and the natural aggregation of Dictyostelium discoideum.Journal of cell science · 2012Article
- Dictyostelium huntingtin controls chemotaxis and cytokinesis through the regulation of myosin II phosphorylation.Molecular biology of the cell · 2011Article
- Autophosphorylation activates Dictyostelium myosin II heavy chain kinase A by providing a ligand for an allosteric binding site in the alpha-kinase domain.The Journal of biological chemistry · 2011Article
- Crystal structure of the alpha-kinase domain of Dictyostelium myosin heavy chain kinase A.Science signaling · 2010Article
- The alpha-kinase family: an exceptional branch on the protein kinase tree.Cellular and molecular life sciences : CMLS · 2010Review
- WD repeat domain of Dictyostelium myosin heavy chain kinase C functions in both substrate targeting and cellular localization.Eukaryotic cell · 2010Article
- EppA, a putative substrate of DdERK2, regulates cyclic AMP relay and chemotaxis in Dictyostelium discoideum.Eukaryotic cell · 2006Article
- Myosin heavy-chain kinase A from Dictyostelium possesses a novel actin-binding domain that cross-links actin filaments.The Biochemical journal · 2006Article
- Multiple myosin II heavy chain kinases: roles in filament assembly control and proper cytokinesis in Dictyostelium.Molecular biology of the cell · 2005Article
- Identification and characterization of a novel alpha-kinase with a von Willebrand factor A-like motif localized to the contractile vacuole and Golgi complex in Dictyostelium discoideum.Molecular biology of the cell · 2005Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have cloned a full-length cDNA encoding a novel myosin II heavy chain kinase (mhckC) from Dictyostelium. Like other members of the myosin heavy chain kinase family, the mhckC gene product, MHCK C, has a kinase domain in its N-terminal half and six WD repeats in the C-terminal half. GFP-MHCK C fusion protein localized to the cortex of interphase cells, to the cleavage furrow of mitotic cells, and to the posterior of migrating cells. These distributions of GFP-MHCK C always corresponded with that of myosin II filaments and were not observed in myosin II-null cells, where GFP-MHCK C was diffusely distributed in the cytoplasm. Thus, localization of MHCK C seems to be myosin II-dependent. Cells lacking the mhckC gene exhibited excessive aggregation of myosin II filaments in the cleavage furrows and in the posteriors of the daughter cells once cleavage was complete. The cleavage process of these cells took longer than that of wild-type cells. Taken together, these findings suggest MHCK C drives the disassembly of myosin II filaments for efficient cytokinesis and recycling of myosin II that occurs during cytokinesis.
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Registered trials
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