ArticleProceedings of the National Academy of Sciences of the United States of America2002
POTE, a highly homologous gene family located on numerous chromosomes and expressed in prostate, ovary, testis, placenta, and prostate cancer.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Genomic Landscape Comparison of Cardiac versus Extra-Cardiac Angiosarcomas.Biomedicines · 2023Article
- Analysis of Minor Proteins Present in Breast Milk by Using WGA Lectin.Children (Basel, Switzerland) · 2022Article
- Phospholipid Scramblases: Role in Cancer Progression and Anticancer Therapeutics.Frontiers in genetics · 2022Review
- Primate-specific POTE-actin gene could play a role in human folliculogenesis by controlling the proliferation of granulosa cells.Cell death discovery · 2021Article
- Molecular characterization of a complex small supernumerary marker chromosome derived from chromosome 18p: an addition to the literature.Molecular cytogenetics · 2021Article
- Article
- POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling.Cell death & disease · 2019Article
- Linkage analysis revealed risk loci on 6p21 and 18p11.2-q11.2 in familial colon and rectal cancer, respectively.European journal of human genetics : EJHG · 2019Article
- Article
- Epigenetic activation of POTE genes in ovarian cancer.Epigenetics · 2019Article
- Expression of the POTE gene family in human ovarian cancer.Scientific reports · 2018Article
- Down-regulation of POTEG predicts poor prognosis in esophageal squamous cell carcinoma patients.Molecular carcinogenesis · 2018Article
- Cross resistance to diverse anticancer nicotinamide phosphoribosyltransferase inhibitors induced by FK866 treatment.Oncotarget · 2018Article
- Proteomic differences in amyloid plaques in rapidly progressive and sporadic Alzheimer's disease.Acta neuropathologica · 2017Article
- Androgen-induced lncRNA POTEF-AS1 regulates apoptosis-related pathway to facilitate cell survival in prostate cancer cells.Cancer science · 2017Article
- Mouse models of Down syndrome: gene content and consequences.Mammalian genome : official journal of the International Mammalian Genome Society · 2016Review
- Increased alpha-defensin expression is associated with risk of coronary heart disease: a feasible predictive inflammatory biomarker of coronary heart disease in hyperlipidemia patients.Lipids in health and disease · 2016Article
- Kisspeptin Activates Ankrd 26 Gene Expression in Migrating Embryonic GnRH Neurons.Frontiers in endocrinology · 2016Article
- Human Ribosomal Proteins RPeL27, RPeL43, and RPeL41 Are Upregulated in Nasopharyngeal Carcinoma Cell Lines.Disease markers · 2016Article
- Targeting cancer testis antigens for biomarkers and immunotherapy in colorectal cancer: Current status and challenges.World journal of gastrointestinal oncology · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
7 authors.
Funding
Abstract
We have identified a gene located on chromosomes 21 that is expressed in normal and neoplastic prostate, and in normal testis, ovary, and placenta. We name this gene POTE (expressed in prostate, ovary, testis, and placenta). The POTE gene has 11 exons and 10 introns and spans approximately equal 32 kb of chromosome 21q11.2 region. The 1.83-kb mRNA of POTE encodes a protein of 66 kDa. Ten paralogs of the gene have been found dispersed among eight different chromosomes (2, 8, 13, 14, 15, 18, 21, and 22) with preservation of ORFs and splice junctions. The synonymous:nonsynonymous ratio indicates that the genes were duplicated rather recently but are diverging at a rate faster than the average for other paralogous genes. In prostate and in testis, at least five different paralogs are expressed. In situ hybridization shows that POTE is expressed in basal and terminal cells of normal prostate epithelium. It is also expressed in some prostate cancers and in the LnCAP prostate cancer cell line. The POTE protein contains seven ankyrin repeats between amino acids 140 and 380. Expression of POTE in prostate cancer and its undetectable expression in normal essential tissues make POTE a candidate for the immunotherapy of prostate cancer. The existence of a large number of closely related but rapidly diverging members, their location on multiple chromosomes and their limited expression pattern suggest an important role for the POTE gene family in reproductive processes.
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