ArticleProceedings of the National Academy of Sciences of the United States of America2002
Associations between human disease genes and overlapping gene groups and multiple amino acid runs.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Guidance for estimating penetrance of monogenic disease-causing variants in population cohorts.Nature genetics · 2024Review
- Case report of kabuki syndrome in a newborn caused by KMT2D gene mutation.Frontiers in pediatrics · 2024Article
- Discovery of long non-coding RNAs in the liver fluke, Fasciola hepatica.PLoS neglected tropical diseases · 2023Article
- Amino acid homorepeats in proteins.Nature reviews. Chemistry · 2020Review
- Overlapping protein-coding genes in human genome and their coincidental expression in tissues.Scientific reports · 2019Article
- Association of polyalanine and polyglutamine coiled coils mediates expansion disease-related protein aggregation and dysfunction.Human molecular genetics · 2014Article
- Overlapping genes of Aedes aegypti: evolutionary implications from comparison with orthologs of Anopheles gambiae and other insects.BMC evolutionary biology · 2013Article
- Spatial localization of genes determined by intranuclear DNA fragmentation with the fusion proteins lamin KRED and histone KRED und visible light.International journal of medical sciences · 2013Article
- An overview of nested genes in eukaryotic genomes.Eukaryotic cell · 2009Review
- Performance and scalability of discriminative metrics for comparative gene identification in 12 Drosophila genomes.PLoS computational biology · 2008Article
- Interactions between homopolymeric amino acids (HPAAs).Protein science : a publication of the Protein Society · 2007Article
- Fast sequence evolution of Hox and Hox-derived genes in the genus Drosophila.BMC evolutionary biology · 2006Article
- The human ortholog of the rodent testis-specific ABC transporter Abca17 is a ubiquitously expressed pseudogene (ABCA17P) and shares a common 5' end with ABCA3.BMC molecular biology · 2006Article
- ELMOD2 is a candidate gene for familial idiopathic pulmonary fibrosis.American journal of human genetics · 2006Article
- The silence RNA keeps: cis mechanisms of RNA mediated epigenetic silencing in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2006Review
- Association study of polymorphisms in synaptic vesicle-associated genes, SYN2 and CPLX2, with schizophrenia.Behavioral and brain functions : BBF · 2005Article
- Speeding disease gene discovery by sequence based candidate prioritization.BMC bioinformatics · 2005Article
- Family-based association study of synapsin II and schizophrenia.American journal of human genetics · 2004Article
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4 authors.
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Abstract
Overlapping gene groups (OGGs) arise when exons of one gene are contained within the introns of another. Typically, the two overlapping genes are encoded on opposite DNA strands. OGGs are often associated with specific disease phenotypes. In this report, we identify genes with OGG architecture and genes encoding multiple long amino acid runs and examine their relations to diseases. OGGs appear to be susceptible to genomic rearrangements as happens commonly with the loci of the DiGeorge syndrome on human chromosome 22. We also examine the degree of conservation of OGGs between human and mouse. Our analyses suggest that (i) a high proportion of genes in OGG regions are disease-associated, (ii) genomic rearrangements are likely to occur within OGGs, possibly as a consequence of anomalous sequence features prevalent in these regions, and (iii) multiple amino acid runs are also frequently associated with pathologies.
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