ArticleCellular and molecular neurobiology2002
Neuroprotective effect of GMP in hippocampal slices submitted to an in vitro model of ischemia.
Article in Cellular and molecular neurobiology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 47 citations in OpenAlex.
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- Lessons from the physiological role of guanosine in neurodegeneration and cancer: Toward a multimodal mechanism of action?Purinergic signalling · 2025Review
- Guanosine Neuroprotective Action in Hippocampal Slices Subjected to Oxygen and Glucose Deprivation Restores ATP Levels, Lactate Release and Glutamate Uptake Impairment: Involvement of Nitric Oxide.Neurochemical research · 2020Article
- Taurine Protects from Pentylenetetrazole-Induced Behavioral and Neurochemical Changes in Zebrafish.Molecular neurobiology · 2019Article
- Folic Acid Protects Against Glutamate-Induced Excitotoxicity in Hippocampal Slices Through a Mechanism that Implicates Inhibition of GSK-3β and iNOS.Molecular neurobiology · 2018Article
- Guanosine prevents nitroxidative stress and recovers mitochondrial membrane potential disruption in hippocampal slices subjected to oxygen/glucose deprivation.Purinergic signalling · 2016Article
- Novel antiepileptic drug lacosamide exerts neuroprotective effects by decreasing glial activation in the hippocampus of a gerbil model of ischemic stroke.Experimental and therapeutic medicine · 2015Article
- Purine receptors are required for DHA-mediated neuroprotection against oxygen and glucose deprivation in hippocampal slices.Purinergic signalling · 2015Article
- Anxiogenic-like profile of Wistar adult rats based on the pilocarpine model: an animal model for trait anxiety?Psychopharmacology · 2013Article
- Protective effects of a novel synthetic α-lipoic acid-decursinol hybrid compound in experimentally induced transient cerebral ischemia.Cellular and molecular neurobiology · 2012Article
- Cooperation of non-effective concentration of glutamatergic system modulators and antioxidant against oxidative stress induced by quinolinic acid.Neurochemical research · 2012Article
- Effects of 3 weeks GMP oral administration on glutamatergic parameters in mice neocortex.Purinergic signalling · 2012Article
- Glutamate-induced toxicity in hippocampal slices involves apoptotic features and p38 MAPK signaling.Neurochemical research · 2008Article
- Intracerebroventricular guanine-based purines protect against seizures induced by quinolinic acid in mice.Neurochemical research · 2005Article
- Neurotoxicity induced by glutamate in glucose-deprived rat hippocampal slices is prevented by GMP.Neurochemical research · 2005Article
- Plasticity of purine release during cerebral ischemia: clinical implications?Journal of cellular and molecular medicineReview
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Guanosine-5'-monophosphate (GMP) was evaluated as a neuroprotective agent against the damage observed in rat hippocampal slices submitted to an in vitro model of ischemia with or without the presence of the ionotropic glutamate receptor agonist, Kainic acid (KA). 2. Cellular injury was evaluated by MTT reduction, lactate dehydrogenase(LDH) release assay, and measurement of intracellular ATP levels. 3. In slices submitted to ischemic conditions, 1 mM GMP partially prevented the decrease in cell viability induced by glucose and oxygen deprivation and the addition of KA. 4. KA or N-methyl-D-aspartate (NMDA) receptor antagonists, gamma-D-glutamylamino-methylsulfonate (GAMS) or (+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801, 20 microM) also prevented toxicity in hippocampal slices under ischemic conditions, respectively. 5. The association of GMP with GAMS or MK-801 did not induce additional protection than that observed with GMP or that classical glutamate receptor antagonists alone. 6. GMP, probably by interacting with ionotropic glutamate receptors, attenuated the damage caused by glucose and oxygen deprivation in hippocampal slices. This neuroprotective action of GMP in this model of excitotoxicity is of outstanding interest in the search for effective therapies against ischemic injury.
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