ArticleThe Plant cell2002
Empty pericarp2 encodes a negative regulator of the heat shock response and is required for maize embryogenesis.
Article in The Plant cell, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 78 citations in OpenAlex.
- Adaptive response to long-term high temperatures during the reproductive development in Arabidopsis thaliana.Planta · 2026Article
- Elucidating the patterns of pleiotropy and its biological relevance in maize.PLoS genetics · 2023Article
- A Systemic Investigation of Genetic Architecture and Gene Resources Controlling Kernel Size-Related Traits in Maize.International journal of molecular sciences · 2023Article
- Heat shock factor binding proteinFrontiers in plant science · 2023Article
- Arabidopsis HEAT SHOCK FACTOR BINDING PROTEIN is required to limit meiotic crossovers and HEI10 transcription.The EMBO journal · 2022Article
- Response of Tomato (Plants (Basel, Switzerland) · 2022Article
- Fine mapping of a kernel length-related gene with potential value for maize breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2021Article
- Maize kernel development.Molecular breeding : new strategies in plant improvement · 2021Review
- Association Mapping and Transcriptome Analysis Reveal the Genetic Architecture of Maize Kernel Size.Frontiers in plant science · 2021Article
- Analysis of the genetic architecture of maize kernel size traits by combined linkage and association mapping.Plant biotechnology journal · 2020Article
- Mapping of QTL for kernel abortion caused by in vivo haploid induction in maize (Zea mays L.).PloS one · 2020Article
- Article
- Peg Biology: Deciphering the Molecular Regulations Involved During Peanut Peg Development.Frontiers in plant science · 2019Review
- Characterization and fine mapping of qkc7.03: a major locus for kernel cracking in maize.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Pectin Methylesterases: Cell Wall Remodeling Proteins Are Required for Plant Response to Heat Stress.Frontiers in plant science · 2018Review
- The Conserved and Unique Genetic Architecture of Kernel Size and Weight in Maize and Rice.Plant physiology · 2017Article
- Candidate Loci for Yield-Related Traits in Maize Revealed by a Combination of MetaQTL Analysis and Regional Association Mapping.Frontiers in plant science · 2017Article
- A mutational approach for the detection of genetic factors affecting seed size in maize.Plant reproduction · 2016Article
- Transcriptome profiling of peanut gynophores revealed global reprogramming of gene expression during early pod development in darkness.BMC genomics · 2013Article
- Empty pericarp5 encodes a pentatricopeptide repeat protein that is required for mitochondrial RNA editing and seed development in maize.The Plant cell · 2013Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The heat shock response (HSR) is an evolutionarily conserved molecular/biochemical reaction to thermal stress that is essential to the survival of eukaryotic organisms. Recessive Mutator transposon mutations at the maize empty pericarp2 (emp2) locus led to dramatically increased expression of heat shock genes, retarded embryo development, and early-stage abortion of embryogenesis. The developmental timing of emp2 mutant embryo lethality was correlated with the initial competence of maize kernels to invoke the HSR. Cloning and sequence analyses revealed that the emp2 gene encoded a predicted protein with high similarity to HEAT SHOCK BINDING PROTEIN1, which was first described in animals as a negative regulator of the HSR. emp2 is a loss-of-function mutation of an HSR-negative regulator in plants. Despite the recessive emp2 phenotype, steady state levels of emp2 transcripts were abundant in mutant kernels, and the predicted coding region was unaffected. These expression data suggest that emp2 transcription is feedback regulated, whereas S1 nuclease mapping suggests that emp2 mutant transcripts are 5' truncated and nontranslatable. In support of this model, immunoblot assays revealed that EMP2 protein did not accumulate in mutant kernels. These data support a model whereby an unattenuated HSR results in the early abortion of emp2 mutant embryos. Furthermore, the developmental retardation of emp2 mutant kernels before the HSR suggests an additional role for EMP2 during embryo development distinct from the HSR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.