ArticleMediators of inflammation2002
Differential expression and upregulation of interleukin-1alpha, interleukin-1beta and interleukin-6 by freshly isolated human small intestinal epithelial cells.
Article in Mediators of inflammation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 13 citations in OpenAlex.
- Ethanolic Extract ofNutrients · 2020Article
- AnBioscience of microbiota, food and health · 2017Article
- In vitro evaluation of immunological properties of extracellular polysaccharides produced by Lactobacillus delbrueckii strains.Bioscience of microbiota, food and health · 2015Article
- Exogenous interleukin-6 facilitated the contraction of the colon in a depression rat model.Digestive diseases and sciences · 2013Article
- From model cell line to in vivo gene expression: disease-related intestinal gene expression in IBD.Genes and immunity · 2008Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
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Abstract
backgroundSmall intestinal epithelial cells (SIEC) may contribute to local immune regulation.
aimTo examine production of interleukin (IL)-1alpha, IL-1beta and IL-6 by freshly isolated human SIEC.
methodsIL-1alpha and IL-1beta mRNA in epithelial layers (EL) prepared from small intestine and in intestinal epithelial cell (EC) lines were examined by reverse transcription-polymerase chain reaction. IL-1alpha, IL-1beta and IL-6 protein expression by SIEC was examined by flow cytometry before and after activation with lipopolysaccharide and epithelial growth factor.
resultsIL-1alpha and IL-1beta mRNA was detected in EL and EC lines. Background expression of IL-1alpha and IL-1beta protein by SIEC was observed, which did not increase even following activation. IL-6 protein was expressed by SIEC, in a proportion that increased in two out of three samples following activation.
conclusionsIL-6 expression and the presence of IL-1alpha and IL-1beta mRNA suggest a role for SIEC in the regulation of local inflammation.
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