ArticleOncogene2002
Stable and unstable pools of Myc protein exist in human cells.
Article in Oncogene, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- MYC serine 62 phosphorylation promotes its association with DNA double-strand breaks to facilitate repair and cell survival under genotoxic stress.Genes & development · 2026Article
- MYC acetylated lysine residues drive oncogenic cell transformation and regulate select genetic programs for cell adhesion-independent growth and survival.Genes & development · 2023Article
- MYC: a complex problem.Trends in cell biology · 2023Review
- Post-translational modification localizes MYC to the nuclear pore basket to regulate a subset of target genes involved in cellular responses to environmental signals.Genes & development · 2018Article
- High-Risk Human Papillomaviral Oncogenes E6 and E7 Target Key Cellular Pathways to Achieve Oncogenesis.International journal of molecular sciences · 2018Review
- Protein phosphatases at the nuclear envelope.Biochemical Society transactions · 2018Review
- Direct HPV E6/Myc interactions induce histone modifications, Pol II phosphorylation, and hTERT promoter activation.Oncotarget · 2017Article
- Family matters: How MYC family oncogenes impact small cell lung cancer.Cell cycle (Georgetown, Tex.) · 2017Review
- KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents.Oncotarget · 2017Article
- Calcium-dependent binding of Myc to calmodulin.Oncotarget · 2017Article
- Touch and go: nuclear proteolysis in the regulation of metabolic genes and cancer.FEBS letters · 2016Review
- Interferon-γ-induced p27KIP1 binds to and targets MYC for proteasome-mediated degradation.Oncotarget · 2016Article
- Serine 62-Phosphorylated MYC Associates with Nuclear Lamins and Its Regulation by CIP2A Is Essential for Regenerative Proliferation.Cell reports · 2015Article
- Partition of Myc into immobile vs. mobile complexes within nuclei.Scientific reports · 2013Article
- Article
- TLX1 and NOTCH coregulate transcription in T cell acute lymphoblastic leukemia cells.Molecular cancer · 2010Article
- Systematic analysis of essential genes reveals important regulators of G protein signaling.Molecular cell · 2010Article
- Inference of cell cycle-dependent proteolysis by laser scanning cytometry.Experimental cell research · 2009Article
- Sensing and integration of Erk and PI3K signals by Myc.PLoS computational biology · 2008Article
- Kinetics of albumin- and alpha-fetoprotein-production during rat liver development.Histochemistry and cell biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The oncoprotein transcription factor Myc plays a crucial role in the control of cell growth and proliferation. Consistent with its potent growth-promoting properties, cells have evolved a number of mechanisms to limit the activity and accumulation of the Myc protein. One of the most striking of these mechanisms is ubiquitin (Ub)-mediated proteolysis, which typically destroys Myc within minutes of its synthesis. Here we show that, despite the extreme instability of the Myc protein, cells contain a pool of Myc that is metabolically stable. Entry of Myc into the stable pool is signaled by an element within the carboxy-terminus of the protein, and is a cell-specific process that is regulated during mitosis and by interaction with Max. These data demonstrate that - even for a rapidly turned-over protein such as Myc - metabolically stable and unstable forms of a protein can co-exist in cells, and suggest that the rate of destruction of Myc molecules is linked to their specific functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.