ArticleNucleic acids research2002
Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity.
Article in Nucleic acids research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- ALKBH1 Gene rs6494 T>A Polymorphism Decreases Wilms Tumour Risk in Chinese Children.Journal of cellular and molecular medicine · 2025Article
- RNA modification writer-based immunological profile and genomic landscape of tumor microenvironment in lung adenocarcinoma.Discover oncology · 2025Article
- Truncating the spliceosomal 'rope protein' Prp45 results in Htz1 dependent phenotypes.RNA biology · 2024Article
- SKIP Silencing Decreased Disease Resistance AgainstFrontiers in plant science · 2020Article
- Ski mediates TGF-β1-induced fibrosarcoma cell proliferation and promotes tumor growth.Journal of Cancer · 2020Article
- SNW1 is a prognostic biomarker in prostate cancer.Diagnostic pathology · 2019Article
- The human papillomavirus E7 oncoprotein as a regulator of transcription.Virus research · 2017Review
- Epstein-Barr Virus: Diseases Linked to Infection and Transformation.Frontiers in microbiology · 2016Review
- Up-regulation of SKIP relates to retinal ganglion cells apoptosis after optic nerve crush in vivo.Journal of molecular histology · 2014Article
- Expression and prognostic role of SKIP in human breast carcinoma.Journal of molecular histology · 2014Article
- AtSKIP functions as a mediator between cytokinin and light signaling pathway in Arabidopsis thaliana.Plant cell reports · 2014Article
- SKIP expression is correlated with clinical prognosis in patients with bladder cancer.International journal of clinical and experimental pathology · 2014Article
- Spatiotemporal expression of SKIP after rat sciatic nerve crush.Neurochemical research · 2013Article
- Up-regulation of ski-interacting protein in rat brain cortex after traumatic brain injury.Journal of molecular histology · 2013Article
- High SKIP expression is correlated with poor prognosis and cell proliferation of hepatocellular carcinoma.Medical oncology (Northwood, London, England) · 2013Article
- SKIP counteracts p53-mediated apoptosis via selective regulation of p21Cip1 mRNA splicing.Genes & development · 2011Article
- Article
- Phosphoproteomics profiling of human skin fibroblast cells reveals pathways and proteins affected by low doses of ionizing radiation.PloS one · 2010Article
- Xenopus skip modulates Wnt/beta-catenin signaling and functions in neural crest induction.The Journal of biological chemistry · 2010Article
- The RB/E2F pathway and regulation of RNA processing.Biochemical and biophysical research communications · 2009Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Ski interacting protein (Skip) plays an important role in the transforming activity of both v-Ski and EBNA2 (Epstein-Barr virus encoded latency protein) and is involved in EBNA2 and NotchIC activation of CBF1-repressed promoters. We have previously shown that Skip acts as a transcriptional co-activator on a number of cellular and viral promoters. Here, we report that Skip also interacts with pRb and, in cooperation with Ski, can overcome pRb-induced transcriptional repression. We show a strong and direct interaction between pRb and Skip, and we map the site of interaction to amino acid residues 171-353 of the evolutionarily conserved SNW domain of Skip. Furthermore, the combination of Skip and Ski can successfully overcome the G1 arrest and flat cell phenotype induced by pRb. Taken together, these studies suggest that one potential function of the Skip-Ski complex is to overcome the growth-suppressive activities of pRb.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.