ArticleGenome research2002
Extension and integration of the gene ontology (GO): combining GO vocabularies with external vocabularies.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed.
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- Identification of candidate genes and chemicals associated with osteoarthritis by transcriptome-wide association study and chemical-gene interaction analysis.Arthritis research & therapy · 2023Article
- Identification of candidate genes and pathways associated with juvenile idiopathic arthritis by integrative transcriptome-wide association studies and mRNA expression profiles.Arthritis research & therapy · 2023Article
- Genes that are Used Together are More Likely to be Fused Together in Evolution by Mutational Mechanisms: A Bioinformatic Test of the Used-Fused Hypothesis.Evolutionary biology · 2023Article
- Identifying susceptibility genes for essential hypertension by transcriptome-wide association study.Biochemistry and biophysics reports · 2022Article
- Identifying celiac disease-related chemicals by transcriptome-wide association study and chemical-gene interaction analyses.Frontiers in genetics · 2022Article
- Identifying Environmental Endocrine Disruptors Associated With the Age at Menarche by Integrating a Transcriptome-Wide Association Study With Chemical-Gene-Interaction Analysis.Frontiers in endocrinology · 2022Article
- The Gene Ontology Resource: 20 years and still GOing strong.Nucleic acids research · 2019Article
- Gene Ontology synonym generation rules lead to increased performance in biomedical concept recognition.Journal of biomedical semantics · 2016Article
- The Cell Ontology 2016: enhanced content, modularization, and ontology interoperability.Journal of biomedical semantics · 2016Article
- Modeling biochemical pathways in the gene ontology.Database : the journal of biological databases and curation · 2016Article
- TermGenie - a web-application for pattern-based ontology class generation.Journal of biomedical semantics · 2014Article
- The Gene Ontology: enhancements for 2011.Nucleic acids research · 2012Article
- Computable visually observed phenotype ontological framework for plants.BMC bioinformatics · 2011Article
- Cross-product extensions of the Gene Ontology.Journal of biomedical informatics · 2011Article
- Hematopoietic cell types: prototype for a revised cell ontology.Journal of biomedical informatics · 2011Article
- Logical development of the cell ontology.BMC bioinformatics · 2011Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Structured vocabulary development enhances the management of information in biological databases. As information grows, handling the complexity of vocabularies becomes difficult. Defined methods are needed to manipulate, expand and integrate complex vocabularies. The Gene Ontology (GO) project provides the scientific community with a set of structured vocabularies to describe domains of molecular biology. The vocabularies are used for annotation of gene products and for computational annotation of sequence data sets. The vocabularies focus on three concepts universal to living systems, biological process, molecular function and cellular component. As the vocabularies expand to incorporate terms needed by diverse annotation communities, species-specific terms become problematic. In particular, the use of species-specific anatomical concepts remains unresolved. We present a method for expansion of GO into areas outside of the three original universal concept domains. We combine concepts from two orthogonal vocabularies to generate a larger, more specific vocabulary. The example of mammalian heart development is presented because it addresses two issues that challenge GO; inclusion of organism-specific anatomical terms, and proliferation of terms and relationships. The combination of concepts from orthogonal vocabularies provides a robust representation of relevant terms and an opportunity for evaluation of hypothetical concepts.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.