ArticleGenome research2002
Generalized gap model for bacterial artificial chromosome clone fingerprint mapping and shotgun sequencing.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed, 29 citations in OpenAlex.
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- Coverage theories for metagenomic DNA sequencing based on a generalization of Stevens' theorem.Journal of mathematical biology · 2013Article
- Separating metagenomic short reads into genomes via clustering.Algorithms for molecular biology : AMB · 2012Article
- Efficient study design for next generation sequencing.Genetic epidemiology · 2011Article
- Read length and repeat resolution: exploring prokaryote genomes using next-generation sequencing technologies.PloS one · 2010Article
- The theory of discovering rare variants via DNA sequencing.BMC genomics · 2009Article
- Statistical aspects of discerning indel-type structural variation via DNA sequence alignment.BMC genomics · 2009Article
- The international barley sequencing consortium--at the threshold of efficient access to the barley genome.Plant physiology · 2009Article
- A genome survey of Moniliophthora perniciosa gives new insights into Witches' Broom Disease of cacao.BMC genomics · 2008Article
- Aspects of coverage in medical DNA sequencing.BMC bioinformatics · 2008Article
- De novo bacterial genome sequencing: millions of very short reads assembled on a desktop computer.Genome research · 2008Article
- Bounds on the distribution of the number of gaps when circles and lines are covered by fragments: theory and practical application to genomic and metagenomic projects.BMC bioinformatics · 2007Article
- Extension of Lander-Waterman theory for sequencing filtered DNA libraries.BMC bioinformatics · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We develop an extension to the Lander-Waterman theory for characterizing gaps in bacterial artificial chromosome fingerprint mapping and shotgun sequencing projects. It supports a larger set of descriptive statistics and is applicable to a wider range of project parameters. We show that previous assertions regarding inconsistency of the Lander-Waterman theory at higher coverages are incorrect and that another well-known but ostensibly different model is in fact the same. The apparent paradox of infinite island lengths is resolved. Several applications are shown, including evolution of the probability density function, calculation of closure probabilities, and development of a probabilistic method for computing stopping points in bacterial artificial chromosome shotgun sequencing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.