ArticleGenome research2002
Rapid mapping of zebrafish mutations with SNPs and oligonucleotide microarrays.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Risk taking behaviour predicts consistent and heritable coping styles in zebrafish.BMC neuroscience · 2025Article
- Maternal regulation of the vertebrate oocyte-to-embryo transition.PLoS genetics · 2024Article
- Allele-specific gene expression can underlie altered transcript abundance in zebrafish mutants.eLife · 2022Article
- Cross-species Exon Capture and Whole Exome Sequencing: Application, Utility and Challenges for Genomic Resource Development in Non-model Species.Marine biotechnology (New York, N.Y.) · 2021Article
- The Laboratory Domestication of Zebrafish: From Diverse Populations to Inbred Substrains.Molecular biology and evolution · 2020Article
- Article
- Heterozygous Single Nucleotide Polymorphic Loci in Haploid Gametophytes ofFrontiers in genetics · 2019Article
- Analysis of Single Nucleotide Variants in CRISPR-Cas9 Edited Zebrafish Exomes Shows No Evidence of Off-Target Inflation.Frontiers in genetics · 2019Article
- Article
- MiSNPDb: a web-based genomic resources of tropical ecology fruit mango (Mangifera indica L.) for phylogeography and varietal differentiation.Scientific reports · 2017Article
- Article
- A countermeasure development pipeline.Annals of the New York Academy of Sciences · 2016Review
- SNPfisher: tools for probing genetic variation in laboratory-reared zebrafish.Development (Cambridge, England) · 2015Article
- Article
- Using next-generation sequencing to isolate mutant genes from forward genetic screens.Nature reviews. Genetics · 2014Review
- Article
- Anti-cancer drug discovery: update and comparisons in yeast, Drosophila, and zebrafish.Current molecular pharmacology · 2014Article
- Transposable elements are major contributors to the origin, diversification, and regulation of vertebrate long noncoding RNAs.PLoS genetics · 2013Article
- Development and Validation of Single Nucleotide Polymorphisms (SNPs) Markers from Two Transcriptome 454-Runs of Turbot (Scophthalmus maximus) Using High-Throughput Genotyping.International journal of molecular sciences · 2013Article
- Mutation mapping and identification by whole-genome sequencing.Genome research · 2012Article
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Authors and funding
8 authors.
Funding
Abstract
Large-scale genetic screens in zebrafish have identified thousands of mutations in hundreds of essential genes. The genetic mapping of these mutations is necessary to link DNA sequences to the gene functions defined by mutant phenotypes. Here, we report two advances that will accelerate the mapping of zebrafish mutations: (1) The construction of a first generation single nucleotide polymorphism (SNP) map of the zebrafish genome comprising 2035 SNPs and 178 small insertions/deletions, and (2) the development of a method for mapping mutations in which hundreds of SNPs can be scored in parallel with an oligonucleotide microarray. We have demonstrated the utility of the microarray technique in crosses with haploid and diploid embryos by mapping two known mutations to their previously identified locations. We have also used this approach to localize four previously unmapped mutations. We expect that mapping with SNPs and oligonucleotide microarrays will accelerate the molecular analysis of zebrafish mutations.
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Registered trials
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