ArticleGenome research2002
Gene expression profiling of embryo-derived stem cells reveals candidate genes associated with pluripotency and lineage specificity.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
59 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analysis of differentiating mouse embryonic stem cell gene expression kinetics reveals early change of a small gene set.PLoS computational biology · 2006Pooled it
- Exploring the differentiation potential of EomesDevelopmental biology · 2025Article
- Offspring production of ovarian organoids derived from spermatogonial stem cells by defined factors with chromatin reorganization.Journal of advanced research · 2021Article
- The Candida albicans biofilm gene circuit modulated at the chromatin level by a recent molecular histone innovation.PLoS biology · 2019Article
- Functional Testing of Primitive Oocyte-like Cells Developed in Ovarian Surface Epithelium Cell Culture from Small VSEL-like Stem Cells: Can They Be Fertilized One Day?Stem cell reviews and reports · 2018Article
- AIMP3 depletion causes genome instability and loss of stemness in mouse embryonic stem cells.Cell death & disease · 2018Article
- A mRNA landscape of bovine embryos after standard and MAPK-inhibited culture conditions: a comparative analysis.BMC genomics · 2015Article
- Bidirectional developmental potential in reprogrammed cells with acquired pluripotency.Nature · 2014Article
- Origins and implications of pluripotent stem cell variability and heterogeneity.Nature reviews. Molecular cell biology · 2013Review
- A focused microarray for screening rat embryonic stem cell lines.Stem cells and development · 2013Article
- Article
- In vitro culture of mouse embryos reduces differential gene expression between inner cell mass and trophectoderm.Reproductive sciences (Thousand Oaks, Calif.) · 2012Article
- Comparative analysis of nuclear transfer embryo-derived mouse embryonic stem cells. Part II: gene regulation.Cellular reprogramming · 2012Article
- Comparative analysis of nuclear transfer embryo-derived mouse embryonic stem cells. Part I: cellular characterization.Cellular reprogramming · 2012Article
- Perivascular human endometrial mesenchymal stem cells express pathways relevant to self-renewal, lineage specification, and functional phenotype.Biology of reproduction · 2012Article
- Fine scale analysis of gene expression in Drosophila melanogaster gonads reveals Programmed cell death 4 promotes the differentiation of female germline stem cells.BMC developmental biology · 2012Article
- Genome-wide profiling of pluripotent cells reveals a unique molecular signature of human embryonic germ cells.PloS one · 2012Article
- Method for obtaining committed adult mesenchymal precursors from skin and lung tissue.PloS one · 2012Article
- Paracrine and epigenetic control of trophectoderm differentiation from human embryonic stem cells: the role of bone morphogenic protein 4 and histone deacetylases.Stem cells and development · 2011Article
- Gatekeeper of pluripotency: a common Oct4 transcriptional network operates in mouse eggs and embryonic stem cells.BMC genomics · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Large-scale gene expression profiling was performed on embryo-derived stem cell lines to identify molecular signatures of pluripotency and lineage specificity. Analysis of pluripotent embryonic stem (ES) cells, extraembryonic-restricted trophoblast stem (TS) cells, and terminally-differentiated mouse embryo fibroblast (MEF) cells identified expression profiles unique to each cell type, as well as genes common only to ES and TS cells. Whereas most of the MEF-specific genes had been characterized previously, the majority (67%) of the ES-specific genes were novel and did not include known differentiated cell markers. Comparison with microarray data from embryonic material demonstrated that ES-specific genes were underrepresented in all stages sampled, whereas TS-specific genes included known placental markers. Investigation of four novel TS-specific genes showed trophoblast-restricted expression in cell lines and in vivo, whereas one uncharacterized ES-specific gene, Esg-1, was found to be exclusively associated with pluripotency. We suggest that pluripotency requires a set of genes not expressed in other cell types, whereas lineage-restricted stem cells, like TS cells, express genes predictive of their differentiated lineage.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.