ArticleGenome research2002
Evidence for a fast, intrachromosomal conversion mechanism from mapping of nucleotide variants within a homogeneous alpha-satellite DNA array.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed.
- Telomere-to-telomere assembly of diploid chromosomes with Verkko.Nature biotechnology · 2023Article
- Review
- Variation and Evolution of Human Centromeres: A Field Guide and Perspective.Annual review of genetics · 2021Review
- Genomic Tackling of Human Satellite DNA: Breaking Barriers through Time.International journal of molecular sciences · 2021Review
- Review
- Automated assembly of centromeres from ultra-long error-prone reads.Nature biotechnology · 2020Article
- Centromere studies in the era of 'telomere-to-telomere' genomics.Experimental cell research · 2020Review
- Centromeres under Pressure: Evolutionary Innovation in Conflict with Conserved Function.Genes · 2020Review
- Characterization of repeat arrays in ultra-long nanopore reads reveals frequent origin of satellite DNA from retrotransposon-derived tandem repeats.The Plant journal : for cell and molecular biology · 2020Article
- Centromere Repeats: Hidden Gems of the Genome.Genes · 2019Review
- The Targeted Sequencing of Alpha Satellite DNA in Cercopithecus pogonias Provides New Insight Into the Diversity and Dynamics of Centromeric Repeats in Old World Monkeys.Genome biology and evolution · 2018Article
- Diversity and distribution of alpha satellite DNA in the genome of an Old World monkey: Cercopithecus solatus.BMC genomics · 2016Article
- Article
- Repression of harmful meiotic recombination in centromeric regions.Seminars in cell & developmental biology · 2016Review
- Organization and evolution of Gorilla centromeric DNA from old strategies to new approaches.Scientific reports · 2015Article
- Centromere reference models for human chromosomes X and Y satellite arrays.Genome research · 2014Article
- Tandem repeats derived from centromeric retrotransposons.BMC genomics · 2013Article
- Dynamic distribution patterns of ribosomal DNA and chromosomal evolution in Paphiopedilum, a lady's slipper orchid.BMC plant biology · 2011Article
- FoSTeS, MMBIR and NAHR at the human proximal Xp region and the mechanisms of human Xq isochromosome formation.Human molecular genetics · 2011Article
- Organization and molecular evolution of CENP-A--associated satellite DNA families in a basal primate genome.Genome biology and evolution · 2011Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Assuming that patterns of sequence variants within highly homogeneous centromeric tandem repeat arrays can tell us which molecular turnover mechanisms are presently at work, we analyzed the alpha-satellite tandem repeat array DXZ1 of one human X chromosome. Here we present accurate snapshots from this dark matter of the genome. We demonstrate stable and representative cloning of the array in a P1 artificial chromosome (PAC) library, use samples of higher-order repeats subcloned from five unmapped PACs (120-160 kb) to identify common variants, and show that such variants are presently in a fixed transition state. To characterize patterns of variant spread throughout homogeneous array segments, we use a novel partial restriction and pulsed-field gel electrophoresis mapping approach. We find an older large-scale (35-50 kb) duplication event supporting the evolutionarily important unequal crossing-over hypothesis, but generally find independent variant occurrence and a paucity of potential de novo mutations within segments of highest homogeneity (99.1%-99.3%). Within such segments, a highly nonrandom variant clustering within adjacent higher-order repeats was found in the absence of haplotypic repeats. Such variant clusters are hardly explained by interchromosomal, fixation-driving mechanisms and likely reflect a fast, localized, intrachromosomal sequence conversion mechanism.
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