ArticleGenome research2002
Interrogating a high-density SNP map for signatures of natural selection.
Article in Genome research, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 442 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
442 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A Meta-Assembly of Selection Signatures in Cattle.PloS one · 2016Pooled it
- Association of positively selected eIF3a polymorphisms with toxicity of platinum-based chemotherapy in NSCLC patients.Acta pharmacologica Sinica · 2015Trial
- Population Differentiation and Polygenic Selection in the Finnish Ayrshire Cows Selected on Genomic Information.Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie · 2026Article
- Whole Genome Sequencing of the Moruga Hill Rice (Biotech (Basel (Switzerland)) · 2026Article
- Genetic structure and selection signatures of Beijing-You chicken populations provide insight into breed conservation.Poultry science · 2026Article
- Genomic Evidence for Natural Selection Underlying High-Altitude Adaptive Hemoglobin Levels Among Peruvian Andeans.Genome biology and evolution · 2026Article
- Article
- Extensive antagonistic variants across the human genome.Nature communications · 2026Article
- Allelic variation at a single locus distinguishes spring and winter faba beans.Nature genetics · 2026Article
- Article
- Whole genome sequencing revealed genetic diversity, population structure, and selective signature of Tianhua mutton sheep.BMC genomics · 2026Article
- Genetic diversity, population structure, and combined detection of selection signatures in Iranian versus Afghan Baluchi sheep.PloS one · 2026Article
- Genetic diversity and population structure of the Taigan dog breed.FEBS open bio · 2025Article
- Comparative genomics reveals common diversity and adaptation to harsh environments in the Arabian Peninsula indigenous chickens.Animal genetics · 2025Article
- Genome-wide locus-allele comparison reveals differential evolution dynamics from annual wild to landrace and released cultivar soybeans.The plant genome · 2025Article
- Whole genome and transcriptome analyses identify genetic markers associated with growth traits in Qinchuan black pig.BMC genomics · 2025Article
- Genomic diversity of Cameroonian Gudali and Gudali-cross cattle.Scientific reports · 2025Article
- Exploring the genetics of social behaviour in C. calcarata.Scientific reports · 2025Article
- Genomic insights into Yanbian cattle: Breed-specific selective sweeps identified by whole-genome sequencing.PloS one · 2025Article
- Selection signatures associated with adaptation in South African Drakensberger, Nguni, and Tuli beef breeds.Tropical animal health and production · 2024Article
382 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Identifying genomic regions that have been targets of natural selection remains one of the most important and challenging areas of research in genetics. To this end, we report an analysis of 26,530 single nucleotide polymorphisms (SNPs) with allele frequencies that were determined in three populations. Specifically, we calculated a measure of genetic differentiation, F(ST), for each locus and examined its distribution at the level of the genome, the chromosome, and individual genes. Through a variety of analyses, we have found statistically significant evidence supporting the hypothesis that selection has influenced extant patterns of human genetic variation. Importantly, by contrasting the F(ST) of individual SNPs to the empirical genome-wide distribution of F(ST), our results are not confounded by tenuous assumptions of population demographic history. Furthermore, we have identified 174 candidate genes with distribution of genetic variation that indicates that they have been targets of selection. Our work provides a first generation natural selection map of the human genome and provides compelling evidence that selection has shaped extant patterns of human genomic variation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.