ArticleBritish journal of pharmacology2002
20-Hydroxyeicosatetraenoic acid potentiates stretch-induced contraction of canine basilar artery via PKC alpha-mediated inhibition of KCa channel.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 58 citations in OpenAlex.
- Impacts of Oxylipins on ischemic stroke: from pathophysiology to clinical phenotypes.Metabolomics : Official journal of the Metabolomic Society · 2025Review
- Bioactive lipids in hypertension.Advances in pharmacology (San Diego, Calif.) · 2023Article
- Eicosanoids in inflammation in the blood and the vessel.Frontiers in pharmacology · 2022Review
- 20-HETE Signals Through G-Protein-Coupled Receptor GPR75 (GCirculation research · 2017Article
- Impaired myogenic response and autoregulation of cerebral blood flow is rescued in CYP4A1 transgenic Dahl salt-sensitive rat.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- Molecular mechanisms of renal blood flow autoregulation.Current vascular pharmacology · 2014Review
- Role of 20-HETE, TRPC channels, and BKCa in dysregulation of pressure-induced Ca2+ signaling and myogenic constriction of cerebral arteries in aged hypertensive mice.American journal of physiology. Heart and circulatory physiology · 2013Article
- Adenosine APhysiological reports · 2013Article
- Adenosine A1 receptors link to smooth muscle contraction via CYP4a, protein kinase C-α, and ERK1/2.Journal of cardiovascular pharmacology · 2013Article
- 20-HETE induces hyperglycemia through the cAMP/PKA-PhK-GP pathway.Molecular endocrinology (Baltimore, Md.) · 2012Article
- 20-HETE increases NADPH oxidase-derived ROS production and stimulates the L-type Ca2+ channel via a PKC-dependent mechanism in cardiomyocytes.American journal of physiology. Heart and circulatory physiology · 2010Article
- 20-hydroxyeicosatetraeonic acid: a new target for the treatment of hypertension.Journal of cardiovascular pharmacology · 2010Review
- Potassium channels and neurovascular coupling.Circulation journal : official journal of the Japanese Circulation Society · 2010Review
- Calcium-activated potassium channels and endothelial dysfunction: therapeutic options?British journal of pharmacology · 2009Review
- Elevated production of 20-HETE in the cerebral vasculature contributes to severity of ischemic stroke and oxidative stress in spontaneously hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2008Article
- PTH-mediated regulation of Na+-K+-ATPase requires Src kinase-dependent ERK phosphorylation.American journal of physiology. Renal physiology · 2008Article
- Passive stretching produces Akt- and MAPK-dependent augmentations of GLUT4 translocation and glucose uptake in skeletal muscles of mice.Pflugers Archiv : European journal of physiology · 2006Article
- Endogenously produced 20-HETE modulates myogenic and TGF response in microperfused afferent arterioles.Prostaglandins & other lipid mediatorsArticle
- NS-398 reverses hypotension in endotoxemic rats: contribution of eicosanoids, NO, and peroxynitrite.Prostaglandins & other lipid mediatorsArticle
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The present study was undertaken to elucidate whether PKCalpha plays a role in the mechanism of the stretch-induced contraction potentiated by 20-hydroxyeicosatetraenoic acid (20-HETE). The effects of 20-HETE on the canine basilar artery were compared with those of iberiotoxin, a blocker of large conductance Ca(2+)-activated K(+) channels (K(Ca) channels), as this blocker was shown earlier to sensitize these arteries to mechanical stretch. 2. Slow stretch at rates of 0.1 to 3 mm s(-1) did not produce any contraction in normal physiological solution. 3. In the presence of 20-HETE, the slow stretch could produce contraction, which was inhibited by nicardipine, a 1,4-dihydropyridine Ca(2+) channel blocker, and gadolinium, a blocker of stretch-activated cation channels. 4. 20-HETE inhibited whole-cell K(+) current and depolarized the membrane by approximately 10 mV. These effects of 20-HETE were similar to those of iberiotoxin. 5. Calphostin C, an inhibitor of protein kinase C (PKC), inhibited the action of 20-HETE, but not that of iberiotoxin. 6. In response to 20-HETE PKCalpha isoform was translocated from the cytosol to the membrane fraction, which translocation was inhibited by calphostin C. 7. These results suggest that 20-HETE induced sensitization of the canine basilar artery to stretch was caused by PKCalpha-mediated inhibition of K(Ca) channel activity.
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