ArticleBritish journal of pharmacology2002
Inhibitory mechanism of xestospongin-C on contraction and ion channels in the intestinal smooth muscle.
Article in British journal of pharmacology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 47 citations in OpenAlex.
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- Mibefradil alters intracellular calcium concentration by activation of phospholipase C and IPMolecular biomedicine · 2021Article
- Maintenance of homeostatic plasticity at theeLife · 2019Article
- Pulsed infrared releases CaJournal of neurophysiology · 2018Article
- Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells.The Journal of physiology · 2015Article
- Ryanodine Receptor Activation Induces Long-Term Plasticity of Spine Calcium Dynamics.PLoS biology · 2015Article
- Differential regulation of GnRH secretion in the preoptic area (POA) and the median eminence (ME) in male mice.Endocrinology · 2015Article
- Interactions of antagonists with subtypes of inositol 1,4,5-trisphosphate (IP3) receptor.British journal of pharmacology · 2014Article
- M1-muscarinic receptors promote fear memory consolidation via phospholipase C and the M-current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Inositol trisphosphate receptors in smooth muscle cells.American journal of physiology. Heart and circulatory physiology · 2012Review
- Heterogeneous function of ryanodine receptors, but not IP3 receptors, in hamster cremaster muscle feed arteries and arterioles.American journal of physiology. Heart and circulatory physiology · 2011Article
- Full and partial agonists of muscarinic M3 receptors reveal single and oscillatory Ca2+ responses by beta 2-adrenoceptors.The Journal of pharmacology and experimental therapeutics · 2009Article
- Forskolin Changes the Relationship between Cytosolic Ca and Contraction in Guinea Pig Ileum.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2009Article
- 2-Aminoethoxydiphenyl-borate (2-APB) increases excitability in pyramidal neurons.Cell calcium · 2009Article
- Regulation of Ca2+ signaling with particular focus on mast cells.Critical reviews in immunology · 2009Review
- Article
- Localised calcium release events in cells from the muscle of guinea-pig gastric fundus.The Journal of physiology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Xestospongin-C isolated from a marine sponge, Xestospongia sp., has recently been shown to be a membrane-permeable IP(3) receptor inhibitor. In this study we examined the effects of this compound on smooth muscle from guinea-pig ileum. 2. In guinea-pig ileum permeabilized with alpha-toxin, xestospongin-C (3 microM) inhibited contractions induced by Ca(2+) mobilized from sarcoplasmic reticulum (SR) with IP(3) or carbachol with GTP, but not with caffeine. 3. In intact smooth muscle tissue, xestospongin-C (3-10 microM) inhibited carbachol- and high-K+-induced increases in [Ca(2+)](i) and contractions at sustained phase. 4. It also inhibited voltage-dependent inward Ba(2+) currents in a concentration-dependent manner with an IC(50) of 0.63 microM. Xestospongin-C (3-10 microM) had no effect on carbachol-induced inward Ca(2+) currents via non-selective cation channels; but it did reduce voltage-dependent K+ currents in a concentration-dependent manner with an IC(50) of 0.13 microM. 5. These results suggest that xestospongin-C inhibits the IP(3) receptor but not the ryanodine receptor in smooth muscle SR membrane. In intact smooth muscle cells, however, xestospongin-C appears to inhibit voltage-dependent Ca(2+) and K+ currents at a concentration range similar to that at which it inhibits the IP(3) receptor. Xestospongin-C is a selective blocker of the IP(3) receptor in permeabilised cells but not in cells with intact plasma membrane.
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