ArticleDevelopment (Cambridge, England)2003
Dlx proteins position the neural plate border and determine adjacent cell fates.
Article in Development (Cambridge, England), 2003. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 109 citations in OpenAlex.
- The Foxi3 transcription factor is necessary for the fate restriction of placodal lineages at the neural plate border.Development (Cambridge, England) · 2023Article
- Making a head: Neural crest and ectodermal placodes in cranial sensory development.Seminars in cell & developmental biology · 2023Review
- Repressive Interactions Between Transcription Factors Separate Different Embryonic Ectodermal Domains.Frontiers in cell and developmental biology · 2022Article
- Environmental Exposure to Heavy Metals Contributes to Diseases Via Deregulated Wnt Signaling Pathways.Iranian journal of pharmaceutical research : IJPR · 2021Review
- Bimodal function of chromatin remodelereLife · 2020Article
- Building the Border: Development of the Chordate Neural Plate Border Region and Its Derivatives.Frontiers in physiology · 2020Review
- The origin and evolution of vertebrate neural crest cells.Open biology · 2020Review
- Article
- Specifying neural crest cells: From chromatin to morphogens and factors in between.Wiley interdisciplinary reviews. Developmental biology · 2018Review
- A gene regulatory network underlying the formation of pre-placodal ectoderm in Xenopus laevis.BMC biology · 2018Article
- Control of neural crest induction by MarvelD3-mediated attenuation of JNK signalling.Scientific reports · 2018Article
- A systems-level approach reveals new gene regulatory modules in the developing ear.Development (Cambridge, England) · 2017Article
- Article
- From nerve net to nerve ring, nerve cord and brain--evolution of the nervous system.Nature reviews. Neuroscience · 2016Review
- Changing Faces of Transcriptional Regulation Reflected by Zic3.Current genomics · 2015Article
- Transcriptional regulation of cranial sensory placode development.Current topics in developmental biology · 2015Review
- The role of foxi family transcription factors in the development of the ear and jaw.Current topics in developmental biology · 2015Review
- Foxi3 is necessary for the induction of the chick otic placode in response to FGF signaling.Developmental biology · 2014Article
- Setting appropriate boundaries: fate, patterning and competence at the neural plate border.Developmental biology · 2014Review
- Establishing the pre-placodal region and breaking it into placodes with distinct identities.Developmental biology · 2014Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The lateral border of the neural plate is a major source of signals that induce primary neurons, neural crest cells and cranial placodes as well as provide patterning cues to mesodermal structures such as somites and heart. Whereas secreted BMP, FGF and Wnt proteins influence the differentiation of neural and non-neural ectoderm, we show here that members of the Dlx family of transcription factors position the border between neural and non-neural ectoderm and are required for the specification of adjacent cell fates. Inhibition of endogenous Dlx activity in Xenopus embryos with an EnR-Dlx homeodomain fusion protein expands the neural plate into non-neural ectoderm tissue whereas ectopic activation of Dlx target genes inhibits neural plate differentiation. Importantly, the stereotypic pattern of border cell fates in the adjacent ectoderm is re-established only under conditions where the expanded neural plate abuts Dlx-positive non-neural ectoderm. Experiments in which presumptive neural plate was grafted to ventral ectoderm reiterate induction of neural crest and placodal lineages and also demonstrate that Dlx activity is required in non-neural ectoderm for the production of signals needed for induction of these cells. We propose that Dlx proteins regulate intercellular signaling across the interface between neural and non-neural ectoderm that is critical for inducing and patterning adjacent cell fates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.