ArticleThe American journal of pathology2002
Disease-associated prion protein in vessel walls.
Article in The American journal of pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- Risk of transmission of sporadic Creutzfeldt-Jakob disease by surgical procedures: systematic reviews and quality of evidence.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2017Pooled it
- Putaminal diffusion tensor imaging measures predict disease severity across human prion diseases.Brain communications · 2020Article
- Maternal smoking during pregnancy and cord blood DNA methylation: new insight on sex differences and effect modification by maternal folate levels.Epigenetics · 2018Article
- Molecular Pathological Classification of Neurodegenerative Diseases: Turning towards Precision Medicine.International journal of molecular sciences · 2016Review
- Drivers: A Biologically Contextualized, Cross-Inferential View of the Epidemiology of Neurodegenerative Disorders.Journal of Alzheimer's disease : JAD · 2016Article
- The Good, the Bad, and the Ugly of Dendritic Cells during Prion Disease.Journal of immunology research · 2015Review
- Article
- Prion diseases: from protein to cell pathology.The American journal of pathology · 2008Review
- Oral scrapie infection modifies the homeostasis of Peyer's patches' dendritic cells.Histochemistry and cell biology · 2007Article
- Processing of the bovine spongiform encephalopathy-specific prion protein by dendritic cells.Journal of virology · 2006Article
- In vitro methods in the study of viral and prion permeability across the blood-brain barrier.Cellular and molecular neurobiology · 2005Review
- VEGF: a critical player in neurodegeneration.The Journal of clinical investigation · 2004Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human prion diseases like Creutzfeldt-Jakob disease are infectious, inherited, or sporadic neurodegenerative disorders, characterized by the accumulation of an abnormal isoform of the host-encoded prion protein. This affects nervous tissue in sporadic Creutzfeldt-Jakob disease and, additionally, in lymphoid tissue in bovine spongiform encephalopathy-linked variant Creutzfeldt-Jakob disease. Experimental studies have established the involvement of cells of the lymphoid and peripheral nervous system in the transport of prions to their target central nervous system tissue. To evaluate the role of vessel wall-associated mobile cells, we obtained formalin-fixed tissue blocks from various brain regions and/or basal arteries from sporadic, variant and iatrogenic Creutzfeldt-Jakob disease, and unselected control cases. We demonstrate disease-associated prion protein deposits in intracranial vessel walls, in sporadic and variant Creutzfeldt-Jakob disease by performing immunohistochemical staining and paraffin-embedded tissue blotting. Using double immunofluorescence, these deposits co-localize with HLA-DR and S-100 immunoreactive cells in the intima, which are components of the vascular-associated dendritic cell network, as well as with HLA-DR and CD-68 immunopositive macrophages of the intima and media. We conclude that mobile cells in vessel walls like dendritic and monocyte/macrophage lineage cells may be involved in spread of disease-associated prion protein and possibly also of infectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.