ArticleProceedings of the National Academy of Sciences of the United States of America2002
Importance of free actin filament barbed ends for Arp2/3 complex function in platelets and fibroblasts.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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Who cites it
32 citing papers in PubMed, 89 citations in OpenAlex.
- The epithelial NaCell reports · 2023Article
- Rho GTPase Signaling in Platelet Regulation and Implication for Antiplatelet Therapies.International journal of molecular sciences · 2023Review
- Actin capping protein regulates postsynaptic spine development through CPI-motif interactions.Frontiers in molecular neuroscience · 2022Article
- Pharmacologic targeting of Cdc42 GTPase by a small molecule Cdc42 activity-specific inhibitor prevents platelet activation and thrombosis.Scientific reports · 2021Article
- Sensitized mutagenesis screen in Factor V Leiden mice identifies thrombosis suppressor loci.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Deletion of the Arp2/3 complex in megakaryocytes leads to microthrombocytopenia in mice.Blood advances · 2017Article
- Redox regulation of the actin cytoskeleton and its role in the vascular system.Free radical biology & medicine · 2017Review
- Loss of the Arp2/3 complex component ARPC1B causes platelet abnormalities and predisposes to inflammatory disease.Nature communications · 2017Article
- Non-genomic activities of retinoic acid receptor alpha control actin cytoskeletal events in human platelets.Journal of thrombosis and haemostasis : JTH · 2016Article
- Article
- FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.Blood · 2015Article
- Platelet actin nodules are podosome-like structures dependent on Wiskott-Aldrich syndrome protein and ARP2/3 complex.Nature communications · 2015Article
- Wiskott-Aldrich syndrome protein (WASp) controls the delivery of platelet transforming growth factor-β1.The Journal of biological chemistry · 2013Article
- Rho GTPases in platelet function.Journal of thrombosis and haemostasis : JTH · 2013Review
- Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.Cancer cell · 2012Article
- The role of Rac1 in glycoprotein Ib-IX-mediated signal transduction and integrin activation.Arteriosclerosis, thrombosis, and vascular biology · 2012Article
- Does size matter in platelet production?Blood · 2012Review
- A novel interaction between FlnA and Syk regulates platelet ITAM-mediated receptor signaling and function.The Journal of experimental medicine · 2010Article
- Cofilin is a pH sensor for actin free barbed end formation: role of phosphoinositide binding.The Journal of cell biology · 2008Article
- A major role for Scar/WAVE-1 downstream of GPVI in platelets.Journal of thrombosis and haemostasis : JTH · 2007Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
We investigated the effect of actin filament barbed end uncapping on Arp23 complex function both in vivo and in vitro. Arp23 complex redistributes rapidly and uniformly to the lamellar edge of activated wild-type platelets and fibroblasts but clusters in marginal actin filament clumps in gelsolin-null cells. Treatment of gelsolin-null platelets with the negative dominant N-WASp C-terminal CA domain has no effect on their residual actin nucleation activity, placing gelsolin actin filament severing, capping, and uncapping function upstream of Arp23 complex nucleation. Actin filaments capped by gelsolin or the gelsolin homolog CapG fail to enhance Arp23 complex nucleation in vitro, but uncapping of the barbed ends of these actin filaments restores their ability to potentiate Arp23 complex nucleation. We conclude that Arp23 complex contribution to actin filament nucleation in platelets and fibroblasts importantly requires free barbed ends generated by severing and uncapping.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.