Alternative treatment for secretory diarrhea revealed in a new class of CFTR inhibitors.

Qais Al-Awqati

Open access · greenAbstract readComment

In one paragraph

Article in The Journal of clinical investigation, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it

0cells of the map it votes in

7citing papers in PubMed

1.3field-weighted citation impact, top 20% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

Structural mechanisms of CFTR function and dysfunction.The Journal of general physiology · 2018
Review
Drug-induced secretory diarrhea: A role for CFTR.Pharmacological research · 2015
Review
Effects of Small Molecule Calcium-Activated Chloride Channel Inhibitors on Structure and Function of Accessory Cholera Enterotoxin (Ace) of Vibrio cholerae.PloS one · 2015
Article
Convective washout reduces the antidiarrheal efficacy of enterocyte surface-targeted antisecretory drugs.The Journal of general physiology · 2013
Article
Mucosal potassium efflux mediated via Kcnn4 channels provides the driving force for electrogenic anion secretion in colon.American journal of physiology. Gastrointestinal and liver physiology · 2010
Article
Phenylalanine-508 mediates a cytoplasmic-membrane domain contact in the CFTR 3D structure crucial to assembly and channel function.Proceedings of the National Academy of Sciences of the United States of America · 2008
Article
CFTR channel pharmacology: novel pore blockers identified by high-throughput screening.The Journal of general physiology · 2004
Review

4 · The record

Corrections and comments

Comment on
Thiazolidinone CFTR inhibitor identified by high-throughput screening blocks cholera toxin-induced intestinal fluid secretion.2002

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Qais Al-AwqatiDepartment of Medicine, Columbia University, New York, New York 10032, USA. qa1@columbia.edu

Columbia University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Child, PreschoolCholeraCystic FibrosisCystic Fibrosis Transmembrane Conductance RegulatorDiarrheaDrug DesignHumansCFTR protein, humanCystic Fibrosis Transmembrane Conductance Regulator

Identifiers

PMID12464662

DOI10.1172/JCI17301

PMCPMC151641

OpenAlexW2022888148

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.