ReviewJournal of mammary gland biology and neoplasia2002
Do inflammatory cells participate in mammary gland involution?
Review in Journal of mammary gland biology and neoplasia, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
41 citing papers in PubMed, 89 citations in OpenAlex.
- Semaphorin7A and PD-L1 cooperatively drive immunosuppression during mammary involution and breast cancer.Cell reports · 2025Article
- Invited Review: Inflammation and Health in the Transition Period Influence Reproductive Function in Dairy Cows.Animals : an open access journal from MDPI · 2025Review
- Review
- Transcriptional Repression of MFG-E8 Causes Disturbance in the Homeostasis of Cell Cycle Through DOCK/ZP4/STAT Signaling in Buffalo Mammary Epithelial Cells.Frontiers in cell and developmental biology · 2021Article
- Macphatics and PoEMs in Postpartum Mammary Development and Tumor Progression.Journal of mammary gland biology and neoplasia · 2020Review
- Review
- Genomic signature of parity in the breast of premenopausal women.Breast cancer research : BCR · 2019Article
- Mammary Stem Cells in Domestic Animals: The Role of ROS.Antioxidants (Basel, Switzerland) · 2018Review
- Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.Journal of cellular physiology · 2018Article
- Stromal cells in breast cancer as a potential therapeutic target.Oncotarget · 2018Review
- The innate and adaptive infiltrating immune systems as targets for breast cancer immunotherapy.Endocrine-related cancer · 2017Review
- The protective effect of longer duration of breastfeeding against pregnancy-associated triple negative breast cancer.Oncotarget · 2016Review
- Analysis of human breast milk cells: gene expression profiles during pregnancy, lactation, involution, and mastitic infection.Functional & integrative genomics · 2016Article
- Deciphering Pro-Lymphangiogenic Programs during Mammary Involution and Postpartum Breast Cancer.Frontiers in oncology · 2016Review
- Immune cell-mediated protection of the mammary gland and the infant during breastfeeding.Advances in nutrition (Bethesda, Md.) · 2015Review
- Regulation of lipid synthesis genes and milk fat production in human mammary epithelial cells during secretory activation.American journal of physiology. Endocrinology and metabolism · 2013Article
- Mouse mammary gland is refractory to the effects of ethanol after natural lactation.Comparative medicine · 2013Article
- Post-weaning increases in the milk-fat globule EGF-factor VIII on fat globules in mouse milk and in the uptake of the fat globules by HC11 mammary epithelial cells.Journal of biochemistry · 2013Article
- Minireview: Inflammation: an instigator of more aggressive estrogen receptor (ER) positive breast cancers.Molecular endocrinology (Baltimore, Md.) · 2012Review
- Reactive oxygen species initiate luminal but not basal cell death in cultured human mammary alveolar structures: a potential regulator of involution.Cell death & disease · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The processes by which the involuting mammary gland clears residual milk and milk fat, as well as apoptotic cells, have gone largely unstudied in the modern literature. Here we review the evidence for and against the involvement of professional phagocytes of hematopoietic lineage in this process. Additionally we present evidence that mammary epithelial cells themselves are capable of phagocytosis and may be responsible for the majority of apoptotic cell and residual milk clearance during murine involution. In this scheme these cells regulate their cytokine production in response to apoptotic cells in a manner similar to other cells, including macrophages. The ensuing model describes a process of involution that actively suppresses an inflammatory response in the gland, allowing for effective tissue remodeling and damage prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.