ReviewJournal of mammary gland biology and neoplasia2002
Defense of the bovine mammary gland by polymorphonuclear neutrophil leukocytes.
Review in Journal of mammary gland biology and neoplasia, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 72 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
72 citing papers in PubMed, 303 citations in OpenAlex.
- Subclinical mastitis of buffaloes in Asia: prevalence, pathogenesis, risk factors, antimicrobial resistance, and current treatment strategies.Journal of animal science and technology · 2026Review
- Effects of Sodium Alginate Infusion on Intramammary Immunity Against Subclinical Mastitis in Dairy Cows.International journal of molecular sciences · 2025Article
- Relative expression of pro-inflammatory cytokine genes in Holstein dairy cows naturally affected byIranian journal of veterinary research · 2025Article
- Assessing the Usefulness of Interleukin-8 as a Biomarker of Inflammation and Metabolic Dysregulation in Dairy Cows.International journal of molecular sciences · 2024Article
- Reproducible isolation of bovine mammary macrophages for analysis of host pathogen interactions.BMC veterinary research · 2024Article
- Cytokine profile, differential somatic cell count, and oxidative status of Italian Mediterranean buffalo milk affected by the temperature-humidity index.Frontiers in veterinary science · 2024Article
- The mammosphere-derived epithelial cell secretome modulates neutrophil functions in the bovine model.Frontiers in immunology · 2024Article
- Total and Differential Somatic Cell Count in Italian Local Cattle Breeds: Phenotypic Variability and Effect on Milk Yield and Composition.Animals : an open access journal from MDPI · 2023Article
- New Insights on Nucleotide Sequence Variants and mRNA Levels of Candidate Genes Assessing Resistance/Susceptibility to Mastitis in Holstein and Montbéliarde Dairy Cows.Veterinary sciences · 2023Article
- Immunomodulatory Effects of Probiotics: A Novel Preventive Approach for the Control of Bovine Mastitis.Microorganisms · 2022Review
- Article
- Factors Associated with the Severity of Clinical Mastitis.Pathogens (Basel, Switzerland) · 2022Article
- Emerging Roles of Noncoding RNAs in Bovine Mastitis Diseases.Pathogens (Basel, Switzerland) · 2022Review
- Article
- Immune mechanisms, resistance genes, and their roles in the prevention of mastitis in dairy cows.Archives animal breeding · 2022Review
- β-hydroxybutyrate enhances bovine neutrophil adhesion by inhibiting autophagy.Frontiers in immunology · 2022Article
- Association of intrauterine presence of Lactobacillus spp. with inflammation and pathogenic bacteria in the uterus in postpartum dairy cows.The Journal of reproduction and development · 2021Article
- Somatic cell and innate immune responses in mammary glands of lactating cows to intramammary infusion of Bifidobacterium breve at pre-drying off period.The Journal of veterinary medical science · 2021Article
- Efficacy of inactivatedVeterinary research forum : an international quarterly journal · 2021Article
- Immunomodulatory Effects of Herbal Compounds Quercetin and Curcumin on Cellular and Molecular Functions of Bovine-Milk-Isolated Neutrophils towardAnimals : an open access journal from MDPI · 2021Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The primary phagocytic cells of the bovine mammary gland, polymorphonuclear neutrophil leukocytes (PMN), and macrophages, comprise the first line of defense against invading pathogens. In the normal healthy mammary gland, macrophages predominate and act as sentinels to invading mastitis-causing pathogens. Once invaders are detected, macrophages, and possibly mammary epithelial cells, release chemoattractants that direct migration of PMN into the area. In the mammary gland, protection is only effective if rapid influx of PMN from the circulation and subsequent phagocytosis and killing of bacteria occur. The second line of defense against infection consists of a network of memory cells and immunoglobulins that interact with the first line of defense. To minimize mammary tissue damage caused by bacterial toxins and oxidative products released by PMN, elimination of invading bacteria must proceed quickly. Therefore, the inflammatory response needs to be regulated. Hormones, metabolites, and acute phase proteins act to influence the outcome of mastitis, especially around parturition. The number of circulating PMN in cows during early lactation is highly heritable and closely related to susceptibility to clinical mastitis at this time. Advances in molecular biology are making available the tools, techniques, and products to study and modulate host-pathogen interactions. For example, the cloning and expression of proteins such as recombinant bovine soluble (rbos) CD (cluster of differentiation) 14 antigens, may provide ways of minimizing damaging effects of endotoxin during acute coliform mastitis. Soluble CD14 binds and neutralizes lipopolysacharide (LPS) and causes local recruitment of PMN after binding of CD14-LPS complexes to mammary epithelial cells. Development of transgenic animals that express rbosCD14 in their milk could prevent infection by Gram-negative pathogens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.