ReviewNature reviews. Drug discovery2002
Dual-specificity phosphatases as targets for antineoplastic agents.
Review in Nature reviews. Drug discovery, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 140 citations in OpenAlex.
- Smiles-based bioactivity prediction through molecular encoder selection and data augmentation.Journal of cheminformatics · 2026Article
- Identification of Methylstat as a Potential Therapeutic Agent for Human Glioma Cells by Targeting Cell Cycle Arrest.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Induction of the hepatic aryl hydrocarbon receptor by alcohol dysregulates autophagy and phospholipid metabolism via PPP2R2D.Nature communications · 2022Article
- Exposure of the cytoplasm to low-dose X-rays modifies ataxia telangiectasia mutated-mediated DNA damage responses.Scientific reports · 2021Article
- Comparative genomics reveals high biological diversity and specific adaptations in the industrially and medically important fungal genus Aspergillus.Genome biology · 2017Article
- Deregulation of the protein phosphatase 2A, PP2A in cancer: complexity and therapeutic options.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Review
- Inhibition of CDC25B phosphatase through disruption of protein-protein interaction.ACS chemical biology · 2015Article
- Protein tyrosine phosphatases as potential therapeutic targets.Acta pharmacologica Sinica · 2014Review
- Targeting cell division cycle 25 homolog B to regulate influenza virus replication.Journal of virology · 2013Article
- Specific targeting of caspase-9/PP2A interaction as potential new anti-cancer therapy.PloS one · 2013Article
- Prognostic significance of high phosphatase of regenerating liver-3 expression in patients with gastric cancer who underwent curative gastrectomy.Digestive diseases and sciences · 2012Article
- Dual-Specificity Phosphatase CDC25A/B Inhibitor Identified from a Focused Library with Nonelectrophilic Core Structure.ACS medicinal chemistry letters · 2012Article
- Bioinformatic identification of novel protein phosphatases in the dog genome.Molecular and cellular biochemistry · 2011Article
- Development of antiproliferative phenylmaleimides that activate the unfolded protein response.Bioorganic & medicinal chemistry · 2010Article
- Prognostic significance of phosphatase of regenerating liver-3 expression in ovarian cancer.Pathology oncology research : POR · 2009Article
- Synthetic strategies toward carbocyclic purine-pyrimidine hybrid nucleosides.Bioorganic & medicinal chemistry · 2009Article
- Targeting protein serine/threonine phosphatases for drug development.Molecular pharmacology · 2009Review
- Mechanism of Cdc25B phosphatase with the small molecule substrate p-nitrophenyl phosphate from QM/MM-MFEP calculations.The journal of physical chemistry. B · 2009Article
- Bioactivities of simplified adociaquinone B and naphthoquinone derivatives against Cdc25B, MKP-1, and MKP-3 phosphatases.Bioorganic & medicinal chemistry · 2009Article
- Is Cdc25 a druggable target?Anti-cancer agents in medicinal chemistry · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dual-specificity protein phosphatases are a subclass of protein tyrosine phosphatases that are uniquely able to hydrolyse the phosphate ester bond on both a tyrosine and a threonine or serine residue on the same protein. Dual-specificity phosphatases have a central role in the complex regulation of signalling pathways that are involved in cell stress responses, proliferation and death. Although this enzyme family is increasingly the target of drug discovery efforts in pharmaceutical companies, a summary of the salient developments in the biology and medicinal chemistry of dual-specificity phosphatases has been lacking. We hope that this comprehensive overview will stimulate further progress in the development of small-molecule inhibitors that could form the basis for a new class of target-directed therapeutic agents.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.