ArticleProceedings of the National Academy of Sciences of the United States of America2002
Memory-specific temporal profiles of gene expression in the hippocampus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed.
- Opto-CLIP reveals dynamic FMRP regulation of mRNAs upon CA1 neuronal activation.bioRxiv : the preprint server for biology · 2025Article
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- Novel role of NCoR1 in impairing spatial memory through the mediation of a novel interacting protein DEC2.Cellular and molecular life sciences : CMLS · 2024Article
- Transcriptome-wide selection and validation of a solid set of reference genes for gene expression studies in the cephalopod molluskFrontiers in molecular neuroscience · 2023Article
- Article
- Review
- Distinct Transcriptomic Profiles in the Dorsal Hippocampus and Prelimbic Cortex Are Transiently Regulated following Episodic Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Dietary Oligofructose Alone or in Combination with 2'-Fucosyllactose Differentially Improves Recognition Memory and Hippocampal mRNA Expression.Nutrients · 2020Article
- Multiple genetic loci affect place learning and memory performance in Drosophila melanogaster.Genes, brain, and behavior · 2019Article
- Internal Clocks, mGluR7 and Microtubules: A Primer for the Molecular Encoding of Target Durations in Cerebellar Purkinje Cells and Striatal Medium Spiny Neurons.Frontiers in molecular neuroscience · 2019Article
- Temporal Profile of Brain Gene Expression After Prey Catching Conditioning in an Anuran Amphibian.Frontiers in neuroscience · 2019Article
- A novel environment-evoked transcriptional signature predicts reactivity in single dentate granule neurons.Nature communications · 2018Article
- Large-scale transcriptome changes in the process of long-term visual memory formation in the bumblebee, Bombus terrestris.Scientific reports · 2018Article
- NMDA Receptor Subunits Change after Synaptic Plasticity Induction and Learning and Memory Acquisition.Neural plasticity · 2018Review
- A systems level approach to temporal expression dynamics in Drosophila reveals clusters of long term memory genes.PLoS genetics · 2017Article
- Noradrenergic activation of the basolateral amygdala maintains hippocampus-dependent accuracy of remote memory.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Genome-Wide Temporal Expression Profiling inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2017Article
- Systems genetics identifies Hp1bp3 as a novel modulator of cognitive aging.Neurobiology of aging · 2016Article
- Contextual fear conditioning induces differential alternative splicing.Neurobiology of learning and memory · 2016Article
- Fluid consumption and taste novelty determines transcription temporal dynamics in the gustatory cortex.Molecular brain · 2016Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many experiments in the past have demonstrated the requirement of de novo gene expression during the long-term retention of learning and memory. Although previous studies implicated individual genes or genetic pathways in learning and memory, they did not uncover the collective behaviors or patterns of the genes. We have used genome-scale screening to analyze gene expression during spatial learning of rats in the Morris water maze. Our results show distinct temporal gene expression profiles associated with learning and memory. Exogenous administration of one peptide whose sustained increase during memory retention was implicated by microarray analysis, fibroblast growth factor (FGF)-18, improved spatial learning behavior, suggesting that pharmacological modulation of pathways and targets identified may allow new therapeutic approaches for improving learning and memory. Results of this study also suggest that while learning and physical activity involve common groups of genes, the behavior of learning and memory emerges from unique patterns of gene expression across time.
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