ArticleJournal of clinical pathology2002
Reduced bone formation in UK Gulf War veterans: a bone histomorphometric study.
Article in Journal of clinical pathology, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 21 citations in OpenAlex.
- Age- and sex-associated effects of C18 ceramide sphingolipids on osteoclastogenesis in experimental models of Gulf War Illness.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2025Article
- Potential mechanisms linking psychological stress to bone health.International journal of medical sciences · 2021Review
- Article
- Reduced bone formation in UK Gulf War veterans: a bone histomorphometric study.Journal of clinical pathology · 2003Article
- Bone and the Gulf War.Journal of clinical pathology · 2002Article
- The influence of mechanical stimulation on osteocyte apoptosis and bone viability in human trabecular bone.Journal of musculoskeletal & neuronal interactionsArticle
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7 authors at 4 institutions in 2 countries.
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Abstract
aimsGulf War veterans report a high prevalence of musculoskeletal symptoms. The aim of this study was to establish whether there were abnormalities in bone turnover and remodelling in a group of symptomatic subjects who had served in the Gulf War.
methodsIliac crest bone biopsies were obtained from 17 Gulf War veterans who were seeking litigation and compared with those of 13 age and sex matched healthy controls. Bone histomorphometry was performed using image analysis.
resultsCancellous bone area was significantly lower in Gulf War veterans than in control subjects (p = 0.027) and this was associated with a significantly reduced mineral apposition rate (p = 0.002), mean wall width (p < 0.0001), and bone formation rate at the tissue level (p < 0.0001).
conclusionsThese results demonstrate that in this group of Gulf War veterans there was a significant reduction in bone formation at both the cellular and tissue level and this was associated with a reduction in cancellous bone area. The cause of these abnormalities is unknown but might be related to potentially harmful exposures during service in the Gulf War or to changes in life style as a result of chronic ill health. The clinical relevance of the observed reduction in bone formation remains to be established.
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