ArticleInjury prevention : journal of the International Society for Child and Adolescent Injury Prevention2002
Lipid-lowering agents and the risk of hip fracture in a Medicaid population.
Article in Injury prevention : journal of the International Society for Child and Adolescent Injury Prevention, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 3 syntheses or guidelines pooled it, 69 citations in OpenAlex.
- Efficacy of statins for osteoporosis: a systematic review and meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2017Pooled it
- Unintended effects of statins from observational studies in the general population: systematic review and meta-analysis.BMC medicine · 2014 · on this mapPooled it
- Hydroxymethylglutaryl-coenzyme A reductase inhibitors and osteoporosis: a meta-analysis.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2005Pooled it
- Age-dependent effects of atorvastatin on biochemical bone turnover markers: a randomized controlled trial in postmenopausal women.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2004Trial
- Assessing the contributions of modifiable risk factors to serious falls and fragility fractures among older persons living with HIV.Journal of the American Geriatrics Society · 2023Article
- Case-control study examining the association between hip fracture risk and statins therapy in old people.Medicine · 2019Article
- Association of Statin Use and Mortality After Transcatheter Aortic Valve Replacement.Journal of the American Heart Association · 2019 · on this mapObservational
- Assessing Residual Bias in Estimating Influenza Vaccine Effectiveness: Comparison of High-dose Versus Standard-dose Vaccines.Medical care · 2019Article
- High-potency statins but not all statins decrease the risk of new-onset osteoporotic fractures: a nationwide population-based longitudinal cohort study.Clinical epidemiology · 2018Article
- Conditioning on future exposure to define study cohorts can induce bias: the case of low-dose acetylsalicylic acid and risk of major bleeding.Clinical epidemiology · 2017Article
- Wheelchair use and lipophilic statin medications may influence bone loss in chronic spinal cord injury: findings from the FRASCI-bone loss study.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2016Article
- Use of cardioselective β-blockers and overall death and cardiovascular outcomes in patients with COPD: a population-based cohort study.European journal of clinical pharmacology · 2016Article
- Comparative Effectiveness Research Using Observational Data: Active Comparators to Emulate Target Trials with Inactive Comparators.EGEMS (Washington, DC) · 2016Article
- The active comparator, new user study design in pharmacoepidemiology: historical foundations and contemporary application.Current epidemiology reports · 2015Article
- Counterpoint: the treatment decision design.American journal of epidemiology · 2015Article
- Controlling Time-Dependent Confounding by Health Status and Frailty: Restriction Versus Statistical Adjustment.American journal of epidemiology · 2015Article
- Novel applications of statins for bone regeneration.National science review · 2015Article
- Statin use and risk of fracture: a meta-analysis.International journal of clinical and experimental medicine · 2015Article
- Using claims data to predict dependency in activities of daily living as a proxy for frailty.Pharmacoepidemiology and drug safety · 2015Article
- Influence of healthy candidate bias in assessing clinical effectiveness for implantable cardioverter-defibrillators: cohort study of older patients with heart failure.BMJ (Clinical research ed.) · 2014Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
contextThree recent nested case-control studies conducted in automated databases suggest that users of 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have a risk of hip and other osteoporotic fractures half that of non-users of any lipid-lowering drug. However, this comparison may be biased by unmeasured factors associated with treated hyperlipidemias.
objectiveTo compare the risk of hip fracture among users of statins and other lipid-lowering agents, which is less susceptible to bias than the comparisons performed in the previous studies. DESIGN AND
settingRetrospective cohort study conducted in the Tennessee Medicaid program between 1 January 1989 through 31 December 1998. SUBJECTS: New users of all lipid-lowering drugs and randomly selected non-user controls who at baseline were at least 50 years of age and did not have life threatening illness, nursing home residence, or diagnosed dementia or osteoporosis. There were 12506 persons with new use of statins, 4798 with new use of other lipid lowering drugs, and 17280 non-user controls.
main outcome measureFracture of the proximal femur (hip), excluding pathological fractures or those resulting from severe trauma.
resultsDuring 66690 person years of follow up, there were 186 hip fractures (2.8 per 1000). Relative to non-users, the adjusted incidence rate ratios (95% confidence interval) were 0.62 (0.45 to 0.85) for statin users and 0.44 (0.26 to 0.95) for other lipid-lowering drugs. When compared directly with the other drugs, the adjusted incidence rate ratio for statins was 1.42 (0.83-2.43).
conclusionThese data provide evidence that the previously observed protective effect of statins may be explained by unmeasured confounding factors.
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