ArticleJapanese journal of cancer research : Gann2002
Multiparametric in situ mRNA hybridization analysis of gastric biopsies predicts lymph node metastasis in patients with gastric carcinoma.
Article in Japanese journal of cancer research : Gann, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- The prognostic role of matrix metalloproteinase 2 in gastric cancer: a systematic review with meta-analysis.Journal of cancer research and clinical oncology · 2014Pooled it
- VEGFA and VEGFR2 RNAscope determination in gastric cancer.Journal of molecular histology · 2018Article
- Blockade of NF-κB nuclear translocation results in the inhibition of the invasiveness of human gastric cancer cells.Oncology letters · 2013Article
- Effects of LY294002 on the invasiveness of human gastric cancer in vivo in nude mice.World journal of gastroenterology · 2009Article
- Lymph node micrometastasis and its correlation with MMP-2 expression in gastric carcinoma.World journal of gastroenterology · 2006Article
- Expression and correlation of CD44v6, vascular endothelial growth factor, matrix metalloproteinase-2, and matrix metalloproteinase-9 in Krukenberg tumor.World journal of gastroenterology · 2005Article
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6 authors at 2 institutions in 3 countries.
Funding
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Abstract
We examined the expression level of several genes that regulate different steps in metastasis formation in formalin-fixed, paraffin-embedded biopsies of 189 primary human gastric carcinomas prior to surgical resection in patients in whom lymph node metastasis was not evident by endoscopic ultrasound or computed tomography (CT) scan. The expressions of epidermal growth factor receptor (EGF-R), vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2 and E-cadherin were examined by a colorimetric in situ mRNA hybridization technique. The integrity of the mRNAs was verified, leaving 161 (85.2%) patients for study. After gastrectomy, 82 patients had positive lymph nodes and 79 patients had negative lymph nodes. The concurrent expression levels of MMP-2 and E-cadherin mRNAs were significantly higher and lower, respectively, in the metastatic tumors than the non-metastatic tumors. Expression of EGF-R and VEGF was not different between the metastatic and non-metastatic tumors. However, when only the intestinal-type of gastric cancer was evaluated, the level of VEGF mRNA was significantly higher in tumors associated with lymph node metastasis than in those without metastasis. However, a high MMP-2:E-cadherin ratio significantly correlated with lymph node metastasis in both types of gastric cancer. These results suggest that multiparametric in situ hybridization analysis for several metastasis-related genes may allow the preoperative prediction of lymph node metastasis from gastric cancer.
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