ArticleJapanese journal of cancer research : Gann2002
Reduced expression and promoter methylation of p16 gene in Epstein-Barr virus-associated gastric carcinoma.
Article in Japanese journal of cancer research : Gann, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 56 citations in OpenAlex.
- DNA Methylation in Gastric Cancer and Preneoplastic Lesions: Emerging Insights and Future Directions.Cancers · 2026Review
- Profiling of immune related genes silenced in EBV-positive gastric carcinoma identified novel restriction factors of human gammaherpesviruses.PLoS pathogens · 2020Article
- EBNA1 binding and epigenetic regulation of gastrokine tumor suppressor genes in gastric carcinoma cells.Virology journal · 2014Article
- Methylation and Expression of Retinoblastoma and Transforming Growth Factor-β1 Genes in Epstein-Barr Virus-Associated and -Negative Gastric Carcinomas.Gastroenterology research and practice · 2012Article
- EBV-infection in cardiac and non-cardiac gastric adenocarcinomas is associated with promoter methylation of p16, p14 and APC, but not hMLH1.Cellular oncology (Dordrecht, Netherlands) · 2011Article
- Macrophages of multiple sclerosis patients display deficient SHP-1 expression and enhanced inflammatory phenotype.Laboratory investigation; a journal of technical methods and pathology · 2009Article
- Epstein-Barr virus and gastric carcinoma: virus-host interactions leading to carcinoma.Cancer science · 2008Review
- SHP-1 deficiency and increased inflammatory gene expression in PBMCs of multiple sclerosis patients.Laboratory investigation; a journal of technical methods and pathology · 2008Article
- Epstein-Barr virus and gastric carcinoma--viral carcinogenesis through epigenetic mechanisms.International journal of clinical and experimental pathology · 2008Article
- Epstein-Barr virus-associated gastric carcinoma in the remnant stomach: de novo and metachronous gastric remnant carcinoma.Journal of gastroenterology · 2005Article
- Aberrant methylations in cancer cells: where do they come from?Cancer science · 2005Review
- Global and non-random CpG-island methylation in gastric carcinoma associated with Epstein-Barr virus.Cancer science · 2003Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) is a unique type of gastric carcinoma (GC), which is considered to develop in a different pathway from EBV-negative GC. To evaluate a possible role of p16, an inhibitor of G1/S transition of the cell cycle, in the carcinogenesis of EBVaGC, p16-immunohistochemistry and methylation-specific PCR analysis (MSP) were applied to surgically resected gastric carcinomas. When the percentage of p16-positive cells in more than 1000 carcinoma cells was expressed as p16 labeling index (p16-LI), it ranged from 2.5 to 88.1 (mean 42.9+/-24.4) in 70 gastric carcinomas. EBVaGC showed significantly lower values (n=15, 26.1+/ -22.1) than EBV-negative GC (n=55, 47.5+/-23.2) (P=0.0036). Fresh frozen tissues of 55 gastric carcinomas (16 EBVaGC and 39 EBV-negative GC) were further subjected to MSP, to evaluate abnormal methylation of the promoter region of the p16 gene. The frequency of methylation was significantly higher in EBVaGC (14/16) than in EBV-negative GC (9/39) (<0.0001). The methylation-positive carcinomas showed significantly lower p16-LI (35.9+/-21.6) than the unmethylated ones (55.2+/-22.7) (P=0.0014). Thus, a marked decrease of p16 expression, caused by the aberrant methylation of the p16 gene promoter, is closely associated with the development of EBVaGC.
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