ArticleTissue engineering2002
Synthesis, biodegradability, and biocompatibility of lysine diisocyanate-glucose polymers.
Article in Tissue engineering, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 111 citations in OpenAlex.
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- A Novel Polyurethane Expandable Root Canal Sealer.Journal of endodontics · 2021Article
- Syntheses and characterization of anti-thrombotic and anti-oxidative Gastrodin-modified polyurethane for vascular tissue engineering.Bioactive materials · 2021Article
- Photosynthesis-assisted remodeling of three-dimensional printed structures.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Incorporation of fast dissolving glucose porogens and poly(lactic-co-glycolic acid) microparticles within calcium phosphate cements for bone tissue regeneration.Acta biomaterialia · 2018Article
- Injectable, compression-resistant polymer/ceramic composite bone grafts promote lateral ridge augmentation without protective mesh in a canine model.Clinical oral implants research · 2018Article
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- Resorbable Nanocomposites with Bone-Like Strength and Enhanced Cellular Activity.Journal of materials chemistry. B · 2017Article
- A novel bioactive osteogenesis scaffold delivers ascorbic acid, β-glycerophosphate, and dexamethasone in vivo to promote bone regeneration.Oncotarget · 2017Article
- High Modulus Biodegradable Polyurethanes for Vascular Stents: Evaluation of Accelerated in vitro Degradation and Cell Viability of Degradation Products.Frontiers in bioengineering and biotechnology · 2015Article
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- Progress and challenges in biomaterials used for bone tissue engineering: bioactive glasses and elastomeric composites.Progress in biomaterials · 2012Article
- Injectable polyurethane composite scaffolds delay wound contraction and support cellular infiltration and remodeling in rat excisional wounds.Journal of biomedical materials research. Part A · 2012Article
- Characterization of the degradation mechanisms of lysine-derived aliphatic poly(ester urethane) scaffolds.Biomaterials · 2011Article
- Recent advances in synthetic bioelastomers.International journal of molecular sciences · 2009Review
- The effect of the local delivery of platelet-derived growth factor from reactive two-component polyurethane scaffolds on the healing in rat skin excisional wounds.Biomaterials · 2009Article
- Injectable biodegradable polyurethane scaffolds with release of platelet-derived growth factor for tissue repair and regeneration.Pharmaceutical research · 2008Article
- Synthesis and characterization of segmented poly(esterurethane urea) elastomers for bone tissue engineering.Acta biomaterialia · 2007Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The success of a tissue-engineering application depends on the use of suitable biomaterials that degrade in a timely manner and induce the least immunogenicity in the host. With this purpose in mind, we have attempted to synthesize a novel nontoxic biodegradable lysine diisocyanate (LDI)- and glucose-based polymer via polymerization of highly purified LDI with glucose and its subsequent hydration to form a spongy matrix. The LDI-glucose polymer was degradable in aqueous solutions at 37, 22, and 4 degrees C, and yielded lysine and glucose as breakdown products. The degradation products of the LDI-glucose polymer did not significantly affect the pH of the solution. The physical properties of the polymer were found to be adequate for supporting cell growth in vitro, as evidenced by the fact that rabbit bone marrow stromal cells (BMSCs) attached to the polymer matrix, remained viable on its surface, and formed multilayered confluent cultures with retention of their phenotype over a period of 2 to 4 weeks. These observations suggest that the LDI-glucose polymer and its degradation products were nontoxic in vitro. Further examination in vivo over 8 weeks revealed that subcutaneous implantation of hydrated matrix degraded in vivo three times faster than in vitro. The implanted polymer was not immunogenic and did not induce antibody responses in the host. Histological analysis of the implanted polymer showed that LDI-glucose polymer induced a minimal foreign body reaction, with formation of a capsule around the degrading polymer. The results suggest that biodegradable peptide-based polymers can be synthesized, and may potentially find their way into biomedical applications because of their biodegradability and biocompatibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.