ArticleProceedings of the National Academy of Sciences of the United States of America2002
Phospholipase A2 group IIA expression in gastric adenocarcinoma is associated with prolonged survival and less frequent metastasis.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
59 citing papers in PubMed, 183 citations in OpenAlex.
- Trial
- Identification of prognostic biomarkers in gastric cancer using endoscopic biopsy samples.Cancer science · 2008Trial
- Human Group IIA Secreted Phospholipase AInternational journal of molecular sciences · 2026Review
- Integrated machine learning analysis of 30 cell death patterns identifies a novel prognostic signature in glioma.Frontiers in cell and developmental biology · 2025Article
- Article
- Correlation analysis between immune-related genes and cell infiltration revealed prostate cancer immunotherapy biomarkers linked to T cells gamma delta.Scientific reports · 2023Article
- Functional Modulation of Human Macrophages by Secreted Phospholipases ABiomedicines · 2022Review
- Old but New: Group IIA Phospholipase AMetabolites · 2022Review
- Group IIA secreted phospholipase A2 controls skin carcinogenesis and psoriasis by shaping the gut microbiota.JCI insight · 2022Article
- A blood-based transcriptomic signature for noninvasive diagnosis of gastric cancer.British journal of cancer · 2021Article
- Data mining of human plasma proteins generates a multitude of highly predictive aging clocks that reflect different aspects of aging.Aging cell · 2020Article
- Structural and Functional Aspects of Targeting the Secreted Human Group IIA Phospholipase AMolecules (Basel, Switzerland) · 2020Review
- Phosphoglucose isomerase gene expression as a prognostic biomarker of gastric cancer.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2019Article
- Group III phospholipase AScientific reports · 2017Article
- Article
- Analysis of glycero-lysophospholipids in gastric cancerous ascites.Journal of lipid research · 2017Article
- Promoting effect of hepatitis B virus on the expressoin of phospholipase A2 group IIA.Lipids in health and disease · 2017Article
- Lipoquality control by phospholipase AProceedings of the Japan Academy. Series B, Physical and biological sciences · 2017Review
- Systems Pharmacology Dissection of the Integrated Treatment for Cardiovascular and Gastrointestinal Disorders by Traditional Chinese Medicine.Scientific reports · 2016Article
- Antiproliferative Activity of Triterpene Glycoside Nutrient from Monk Fruit in Colorectal Cancer and Throat Cancer.Nutrients · 2016Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We analyzed gene expression patterns in human gastric cancers by using cDNA microarrays representing approximately equal 30,300 genes. Expression of PLA2G2A, a gene previously implicated as a modifier of the Apc(Min/+) (multiple intestinal neoplasia 1) mutant phenotype in the mouse, was significantly correlated with patient survival. We confirmed this observation in an independent set of patient samples by using quantitative RT-PCR. Beyond its potential diagnostic and prognostic significance, this result suggests the intriguing possibility that the activity of PLA2G2A may suppress progression or metastasis of human gastric cancer.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.