ArticleProceedings of the National Academy of Sciences of the United States of America2002
Guiding neuronal growth with light.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2002. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed.
- Investigation of the effect of photobiomodulation therapy with different wavelengths on nerve regeneration: an experimental study.BMC oral health · 2025Article
- Shining Light in Mechanobiology: Optical Tweezers, Scissors, and Beyond.ACS photonics · 2024Review
- Tissues as networks of cells: towards generative rules of complex organ development.Journal of the Royal Society, Interface · 2023Review
- Optical trapping with holographically structured light for single-cell studies.Biophysics reviews · 2023Review
- Infrared Laser Effects on Cell Projection Depend on Irradiation Intermittence and Cell Activity.Cells · 2023Article
- Near-infrared light reduces β-amyloid-stimulated microglial toxicity and enhances survival of neurons: mechanisms of light therapy for Alzheimer's disease.Alzheimer's research & therapy · 2022Article
- Keratinocyte and Fibroblast Wound Healing In Vitro Is Repressed by Non-Optimal Conditions but the Reparative Potential Can Be Improved by Water-Filtered Infrared A.Biomedicines · 2021Article
- Understanding, engineering, and modulating the growth of neural networks: An interdisciplinary approach.Biophysics reviews · 2021Review
- Optical Tweezers Exploring Neuroscience.Frontiers in bioengineering and biotechnology · 2020Review
- Neurite regrowth stimulation by a red-light spot focused on the neuronal cell soma following blue light-induced retraction.Scientific reports · 2019Article
- Effects of near infrared focused laser on the fluorescence of labelled cell membrane.Scientific reports · 2018Article
- Role of extrinsic mechanical force in the development of the RA-I tactile mechanoreceptor.Scientific reports · 2018Article
- Water-filtered infrared-A (wIRA) overcomes swallowing disorders and hypersalivation - a case report.German medical science : GMS e-journal · 2017Article
- Spatial temperature gradients guide axonal outgrowth.Scientific reports · 2016Article
- Microfluidic neurite guidance to study structure-function relationships in topologically-complex population-based neural networks.Scientific reports · 2016Article
- Heat for wounds - water-filtered infrared-A (wIRA) for wound healing - a review.German medical science : GMS e-journal · 2016Review
- Optically-controlled platforms for transfection and single- and sub-cellular surgery.Biophysical reviews · 2015Review
- Triggering of high-speed neurite outgrowth using an optical microheater.Scientific reports · 2015Article
- Directional migration of cancer cells induced by a blue light intensity gradient.Biomedical optics express · 2015Article
- A hybrid computational model to predict chemotactic guidance of growth cones.Scientific reports · 2015Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Control over neuronal growth is a fundamental objective in neuroscience, cell biology, developmental biology, biophysics, and biomedicine and is particularly important for the formation of neural circuits in vitro, as well as nerve regeneration in vivo [Zeck, G. & Fromherz, P. (2001) Proc. Natl. Acad. Sci. USA 98, 10457-10462]. We have shown experimentally that we can use weak optical forces to guide the direction taken by the leading edge, or growth cone, of a nerve cell. In actively extending growth cones, a laser spot is placed in front of a specific area of the nerve's leading edge, enhancing growth into the beam focus and resulting in guided neuronal turns as well as enhanced growth. The power of our laser is chosen so that the resulting gradient forces are sufficiently powerful to bias the actin polymerization-driven lamellipodia extension, but too weak to hold and move the growth cone. We are therefore using light to control a natural biological process, in sharp contrast to the established technique of optical tweezers [Ashkin, A. (1970) Phys. Rev. Lett. 24, 156-159; Ashkin, A. & Dziedzic, J. M. (1987) Science 235, 1517-1520], which uses large optical forces to manipulate entire structures. Our results therefore open an avenue to controlling neuronal growth in vitro and in vivo with a simple, noncontact technique.
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